LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome

Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient’s LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4...

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Autores principales: Dunstan, Sarah J., Tram, Trinh Thi Bich, Thwaites, Guy E., Chau, Tran Thi Hong, Phu, Nguyen Hoan, Hien, Tran Tinh, Farrar, Jeremy J., Wolbers, Marcel, Mai, Nguyen Thi Hoang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370666/
https://www.ncbi.nlm.nih.gov/pubmed/25799317
http://dx.doi.org/10.1371/journal.pone.0118789
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author Dunstan, Sarah J.
Tram, Trinh Thi Bich
Thwaites, Guy E.
Chau, Tran Thi Hong
Phu, Nguyen Hoan
Hien, Tran Tinh
Farrar, Jeremy J.
Wolbers, Marcel
Mai, Nguyen Thi Hoang
author_facet Dunstan, Sarah J.
Tram, Trinh Thi Bich
Thwaites, Guy E.
Chau, Tran Thi Hong
Phu, Nguyen Hoan
Hien, Tran Tinh
Farrar, Jeremy J.
Wolbers, Marcel
Mai, Nguyen Thi Hoang
author_sort Dunstan, Sarah J.
collection PubMed
description Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient’s LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval [CI] 1.05–1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.
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spelling pubmed-43706662015-04-04 LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome Dunstan, Sarah J. Tram, Trinh Thi Bich Thwaites, Guy E. Chau, Tran Thi Hong Phu, Nguyen Hoan Hien, Tran Tinh Farrar, Jeremy J. Wolbers, Marcel Mai, Nguyen Thi Hoang PLoS One Research Article Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient’s LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval [CI] 1.05–1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. Public Library of Science 2015-03-23 /pmc/articles/PMC4370666/ /pubmed/25799317 http://dx.doi.org/10.1371/journal.pone.0118789 Text en © 2015 Dunstan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dunstan, Sarah J.
Tram, Trinh Thi Bich
Thwaites, Guy E.
Chau, Tran Thi Hong
Phu, Nguyen Hoan
Hien, Tran Tinh
Farrar, Jeremy J.
Wolbers, Marcel
Mai, Nguyen Thi Hoang
LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
title LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
title_full LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
title_fullStr LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
title_full_unstemmed LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
title_short LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
title_sort lta4h genotype is associated with susceptibility to bacterial meningitis but is not a critical determinant of outcome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370666/
https://www.ncbi.nlm.nih.gov/pubmed/25799317
http://dx.doi.org/10.1371/journal.pone.0118789
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