Near Infra-Red Photoimmunotherapy with Anti-CEA-IR700 Results in Extensive Tumor Lysis and a Significant Decrease in Tumor Burden in Orthotopic Mouse Models of Pancreatic Cancer

Photoimmunotherapy (PIT) of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vit...

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Detalles Bibliográficos
Autores principales: Maawy, Ali A., Hiroshima, Yukihiko, Zhang, Yong, Heim, Roger, Makings, Lew, Garcia-Guzman, Miguel, Luiken, George A., Kobayashi, Hisataka, Hoffman, Robert M., Bouvet, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370703/
https://www.ncbi.nlm.nih.gov/pubmed/25799218
http://dx.doi.org/10.1371/journal.pone.0121989

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