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Rational Manipulation of mRNA Folding Free Energy Allows Rheostat Control of Pneumolysin Production by Streptococcus pneumoniae

The contribution of specific factors to bacterial virulence is generally investigated through creation of genetic “knockouts” that are then compared to wild-type strains or complemented mutants. This paradigm is useful to understand the effect of presence vs. absence of a specific gene product but c...

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Detalles Bibliográficos
Autores principales:	Amaral, Fábio E., Parker, Dane, Randis, Tara M., Kulkarni, Ritwij, Prince, Alice S., Shirasu-Hiza, Mimi M., Ratner, Adam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370707/ https://www.ncbi.nlm.nih.gov/pubmed/25798590 http://dx.doi.org/10.1371/journal.pone.0119823

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