Cargando…
Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus
Tinnitus is the perception of an internally generated sound that is postulated to emerge as a result of structural and functional changes in the brain. However, the precise pathophysiology of tinnitus remains unknown. Llinas’ thalamocortical dysrhythmia model suggests that neural deafferentation due...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370720/ https://www.ncbi.nlm.nih.gov/pubmed/25799178 http://dx.doi.org/10.1371/journal.pone.0120123 |
_version_ | 1782362924913786880 |
---|---|
author | Zobay, Oliver Palmer, Alan R. Hall, Deborah A. Sereda, Magdalena Adjamian, Peyman |
author_facet | Zobay, Oliver Palmer, Alan R. Hall, Deborah A. Sereda, Magdalena Adjamian, Peyman |
author_sort | Zobay, Oliver |
collection | PubMed |
description | Tinnitus is the perception of an internally generated sound that is postulated to emerge as a result of structural and functional changes in the brain. However, the precise pathophysiology of tinnitus remains unknown. Llinas’ thalamocortical dysrhythmia model suggests that neural deafferentation due to hearing loss causes a dysregulation of coherent activity between thalamus and auditory cortex. This leads to a pathological coupling of theta and gamma oscillatory activity in the resting state, localised to the auditory cortex where normally alpha oscillations should occur. Numerous studies also suggest that tinnitus perception relies on the interplay between auditory and non-auditory brain areas. According to the Global Brain Model, a network of global fronto—parietal—cingulate areas is important in the generation and maintenance of the conscious perception of tinnitus. Thus, the distress experienced by many individuals with tinnitus is related to the top—down influence of this global network on auditory areas. In this magnetoencephalographic study, we compare resting-state oscillatory activity of tinnitus participants and normal-hearing controls to examine effects on spectral power as well as functional and effective connectivity. The analysis is based on beamformer source projection and an atlas-based region-of-interest approach. We find increased functional connectivity within the auditory cortices in the alpha band. A significant increase is also found for the effective connectivity from a global brain network to the auditory cortices in the alpha and beta bands. We do not find evidence of effects on spectral power. Overall, our results provide only limited support for the thalamocortical dysrhythmia and Global Brain models of tinnitus. |
format | Online Article Text |
id | pubmed-4370720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43707202015-04-04 Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus Zobay, Oliver Palmer, Alan R. Hall, Deborah A. Sereda, Magdalena Adjamian, Peyman PLoS One Research Article Tinnitus is the perception of an internally generated sound that is postulated to emerge as a result of structural and functional changes in the brain. However, the precise pathophysiology of tinnitus remains unknown. Llinas’ thalamocortical dysrhythmia model suggests that neural deafferentation due to hearing loss causes a dysregulation of coherent activity between thalamus and auditory cortex. This leads to a pathological coupling of theta and gamma oscillatory activity in the resting state, localised to the auditory cortex where normally alpha oscillations should occur. Numerous studies also suggest that tinnitus perception relies on the interplay between auditory and non-auditory brain areas. According to the Global Brain Model, a network of global fronto—parietal—cingulate areas is important in the generation and maintenance of the conscious perception of tinnitus. Thus, the distress experienced by many individuals with tinnitus is related to the top—down influence of this global network on auditory areas. In this magnetoencephalographic study, we compare resting-state oscillatory activity of tinnitus participants and normal-hearing controls to examine effects on spectral power as well as functional and effective connectivity. The analysis is based on beamformer source projection and an atlas-based region-of-interest approach. We find increased functional connectivity within the auditory cortices in the alpha band. A significant increase is also found for the effective connectivity from a global brain network to the auditory cortices in the alpha and beta bands. We do not find evidence of effects on spectral power. Overall, our results provide only limited support for the thalamocortical dysrhythmia and Global Brain models of tinnitus. Public Library of Science 2015-03-23 /pmc/articles/PMC4370720/ /pubmed/25799178 http://dx.doi.org/10.1371/journal.pone.0120123 Text en © 2015 Zobay et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zobay, Oliver Palmer, Alan R. Hall, Deborah A. Sereda, Magdalena Adjamian, Peyman Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus |
title | Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus |
title_full | Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus |
title_fullStr | Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus |
title_full_unstemmed | Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus |
title_short | Source Space Estimation of Oscillatory Power and Brain Connectivity in Tinnitus |
title_sort | source space estimation of oscillatory power and brain connectivity in tinnitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370720/ https://www.ncbi.nlm.nih.gov/pubmed/25799178 http://dx.doi.org/10.1371/journal.pone.0120123 |
work_keys_str_mv | AT zobayoliver sourcespaceestimationofoscillatorypowerandbrainconnectivityintinnitus AT palmeralanr sourcespaceestimationofoscillatorypowerandbrainconnectivityintinnitus AT halldeboraha sourcespaceestimationofoscillatorypowerandbrainconnectivityintinnitus AT seredamagdalena sourcespaceestimationofoscillatorypowerandbrainconnectivityintinnitus AT adjamianpeyman sourcespaceestimationofoscillatorypowerandbrainconnectivityintinnitus |