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The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia

INTRODUCTION: The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS) formation, and has been shown to influence angiogenesis during tissue ischemia. In ischemic tissues, hypoxia induced angiogenesis is crucial for restoring...

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Detalles Bibliográficos
Autores principales:	Alig, Stefan K., Stampnik, Yvonn, Pircher, Joachim, Rotter, Raffaela, Gaitzsch, Erik, Ribeiro, Andrea, Wörnle, Markus, Krötz, Florian, Mannell, Hanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370726/ https://www.ncbi.nlm.nih.gov/pubmed/25799543 http://dx.doi.org/10.1371/journal.pone.0121113

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