Hepatic Expression of Detoxification Enzymes Is Decreased in Human Obstructive Cholestasis Due to Gallstone Biliary Obstruction

BACKGROUND & AIMS: Levels of bile acid metabolic enzymes and membrane transporters have been reported to change in cholestasis. These alterations (e.g. CYP7A1 repression and MRP4 induction) are thought to be adaptive responses that attenuate cholestatic liver injury. However, the molecular mecha...

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Detalles Bibliográficos
Autores principales: Chai, Jin, Feng, Xinchan, Zhang, Liangjun, Chen, Sheng, Cheng, Ying, He, Xiaochong, Yang, Yingxue, He, Yu, Wang, Huaizhi, Wang, Rongquan, Chen, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370735/
https://www.ncbi.nlm.nih.gov/pubmed/25798860
http://dx.doi.org/10.1371/journal.pone.0120055

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