Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

The lack of success in target-based screening approaches to the discovery of antibacterial agents has led to reemergence of phenotypic screening as a successful approach of identifying bioactive, antibacterial compounds. A challenge though with this route is then to identify the molecular target(s)...

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Detalles Bibliográficos
Autores principales: Mugumbate, Grace, Abrahams, Katherine A., Cox, Jonathan A. G., Papadatos, George, van Westen, Gerard, Lelièvre, Joël, Calus, Szymon T., Loman, Nicholas J., Ballell, Lluis, Barros, David, Overington, John P., Besra, Gurdyal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370846/
https://www.ncbi.nlm.nih.gov/pubmed/25799414
http://dx.doi.org/10.1371/journal.pone.0121492

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