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Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model
A novel class of asymmetric mono-carbonyl analogs of curcumin (AMACs) were synthesized and screened for anti-inflammatory activity. These analogs are chemically stable as characterized by UV absorption spectra. In vitro, compounds 3f, 3m, 4b, and 4d markedly inhibited lipopolysaccharide (LPS)-induce...
Autores principales: | Zhao, Chengguang, Zhang, Yali, Zou, Peng, Wang, Jian, He, Wenfei, Shi, Dengjian, Li, Huameng, Liang, Guang, Yang, Shulin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370917/ https://www.ncbi.nlm.nih.gov/pubmed/25834403 http://dx.doi.org/10.2147/DDDT.S75862 |
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