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Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking
PURPOSE: Evaluating the clinical results of trans-epithelial collagen cross-linking (CXL) and standard CXL in patients with progressive keratoconus. METHODS: This prospective study comprised 20 eyes of 20 patients with progressive keratoconus. Ten eyes were treated by standard CXL and ten by trans-e...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370945/ https://www.ncbi.nlm.nih.gov/pubmed/25834386 http://dx.doi.org/10.2147/OPTH.S73991 |
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author | Rossi, S Orrico, A Santamaria, C Romano, V De Rosa, L Simonelli, F De Rosa, G |
author_facet | Rossi, S Orrico, A Santamaria, C Romano, V De Rosa, L Simonelli, F De Rosa, G |
author_sort | Rossi, S |
collection | PubMed |
description | PURPOSE: Evaluating the clinical results of trans-epithelial collagen cross-linking (CXL) and standard CXL in patients with progressive keratoconus. METHODS: This prospective study comprised 20 eyes of 20 patients with progressive keratoconus. Ten eyes were treated by standard CXL and ten by trans-epithelial cross-linking (TE-CXL, epithelium on) with 1 year of follow-up. All patients underwent complete ophthalmologic testing that included pre- and postoperative uncorrected visual acuity, corrected visual acuity, spherical error, spherical equivalent, corneal astigmatism, simulated maximum, minimum, and average keratometry, coma and spherical aberration, optical pachymetry, and endothelial cell density. Intra-and postoperative complications were recorded. The solution used for standard CXL comprised riboflavin 0.1% and dextran 20.0% (Ricrolin), while the solution for TE-CXL (Ricrolin, TE) comprised riboflavin 0.1%, dextran 15.0%, trometamol (Tris), and ethylenediaminetetraacetic acid. Ultraviolet-A treatment was performed with UV-X System at 3 mW/cm(2). RESULTS: In both the standard CXL group (ten patients, ten eyes; mean age, 30.4±7.3 years) and the TE-CXL group (ten patients, ten eyes; mean age, 28±3.8 years), uncorrected visual acuity and corrected visual acuity improved significantly after treatment. Furthermore, a significant improvement in topographic outcomes, spherical error, and spherical equivalent was observed in both groups at month 12 posttreatment. No significant variations were recorded in other parameters. No complications were noted. CONCLUSION: A 1-year follow-up showed stability of clinical and refractive outcomes after standard CXL and TE-CXL. |
format | Online Article Text |
id | pubmed-4370945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-43709452015-04-01 Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking Rossi, S Orrico, A Santamaria, C Romano, V De Rosa, L Simonelli, F De Rosa, G Clin Ophthalmol Original Research PURPOSE: Evaluating the clinical results of trans-epithelial collagen cross-linking (CXL) and standard CXL in patients with progressive keratoconus. METHODS: This prospective study comprised 20 eyes of 20 patients with progressive keratoconus. Ten eyes were treated by standard CXL and ten by trans-epithelial cross-linking (TE-CXL, epithelium on) with 1 year of follow-up. All patients underwent complete ophthalmologic testing that included pre- and postoperative uncorrected visual acuity, corrected visual acuity, spherical error, spherical equivalent, corneal astigmatism, simulated maximum, minimum, and average keratometry, coma and spherical aberration, optical pachymetry, and endothelial cell density. Intra-and postoperative complications were recorded. The solution used for standard CXL comprised riboflavin 0.1% and dextran 20.0% (Ricrolin), while the solution for TE-CXL (Ricrolin, TE) comprised riboflavin 0.1%, dextran 15.0%, trometamol (Tris), and ethylenediaminetetraacetic acid. Ultraviolet-A treatment was performed with UV-X System at 3 mW/cm(2). RESULTS: In both the standard CXL group (ten patients, ten eyes; mean age, 30.4±7.3 years) and the TE-CXL group (ten patients, ten eyes; mean age, 28±3.8 years), uncorrected visual acuity and corrected visual acuity improved significantly after treatment. Furthermore, a significant improvement in topographic outcomes, spherical error, and spherical equivalent was observed in both groups at month 12 posttreatment. No significant variations were recorded in other parameters. No complications were noted. CONCLUSION: A 1-year follow-up showed stability of clinical and refractive outcomes after standard CXL and TE-CXL. Dove Medical Press 2015-03-18 /pmc/articles/PMC4370945/ /pubmed/25834386 http://dx.doi.org/10.2147/OPTH.S73991 Text en © 2015 Rossi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Rossi, S Orrico, A Santamaria, C Romano, V De Rosa, L Simonelli, F De Rosa, G Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
title | Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
title_full | Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
title_fullStr | Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
title_full_unstemmed | Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
title_short | Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
title_sort | standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370945/ https://www.ncbi.nlm.nih.gov/pubmed/25834386 http://dx.doi.org/10.2147/OPTH.S73991 |
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