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HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion
Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the role of HPIP in colorectal cancer (CRC) is unknown. Here, we report that HPIP is overexpressed in most of CRC patients and predicts poo...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371107/ https://www.ncbi.nlm.nih.gov/pubmed/25800793 http://dx.doi.org/10.1038/srep09429 |
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author | Feng, Yingying Xu, Xiaojie Zhang, Yunjing Ding, Jianhua Wang, Yonggang Zhang, Xiaopeng Wu, Zhe Kang, Lei Liang, Yingchun Zhou, LiYing Song, Santai Zhao, Ke Ye, Qinong |
author_facet | Feng, Yingying Xu, Xiaojie Zhang, Yunjing Ding, Jianhua Wang, Yonggang Zhang, Xiaopeng Wu, Zhe Kang, Lei Liang, Yingchun Zhou, LiYing Song, Santai Zhao, Ke Ye, Qinong |
author_sort | Feng, Yingying |
collection | PubMed |
description | Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the role of HPIP in colorectal cancer (CRC) is unknown. Here, we report that HPIP is overexpressed in most of CRC patients and predicts poor clinical outcome in CRC. HPIP promotes CRC cell proliferation via activation of G1/S and G2/M checkpoint transitions, concomitant with a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. HPIP inhibits CRC cell apoptosis accompanied by the decreased levels of BAX and PIG3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor BCL2. HPIP blocks caspase-3-mediated cleavage of PARP, an important apoptosis marker. HPIP promotes CRC cell migration and invasion, and regulates epithelial-mesenchymal transition (EMT), which plays a critical role in cancer cell migration and invasion. Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation of CRC cell proliferation, migration and EMT. Moreover, HPIP knockdown suppresses colorectal tumor growth in nude mice. These data highlight the important role of HPIP in CRC cell proliferation and progression and suggest that HPIP may be a useful target for CRC therapy. |
format | Online Article Text |
id | pubmed-4371107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43711072015-04-06 HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion Feng, Yingying Xu, Xiaojie Zhang, Yunjing Ding, Jianhua Wang, Yonggang Zhang, Xiaopeng Wu, Zhe Kang, Lei Liang, Yingchun Zhou, LiYing Song, Santai Zhao, Ke Ye, Qinong Sci Rep Article Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was shown to play a role in cancer development and progression. However, the role of HPIP in colorectal cancer (CRC) is unknown. Here, we report that HPIP is overexpressed in most of CRC patients and predicts poor clinical outcome in CRC. HPIP promotes CRC cell proliferation via activation of G1/S and G2/M checkpoint transitions, concomitant with a marked increase of the positive cell cycle regulators, including cyclin D1, cyclin A, and cyclin B1. HPIP inhibits CRC cell apoptosis accompanied by the decreased levels of BAX and PIG3, the inducers of apoptosis, and the increased level of the apoptosis inhibitor BCL2. HPIP blocks caspase-3-mediated cleavage of PARP, an important apoptosis marker. HPIP promotes CRC cell migration and invasion, and regulates epithelial-mesenchymal transition (EMT), which plays a critical role in cancer cell migration and invasion. Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation of CRC cell proliferation, migration and EMT. Moreover, HPIP knockdown suppresses colorectal tumor growth in nude mice. These data highlight the important role of HPIP in CRC cell proliferation and progression and suggest that HPIP may be a useful target for CRC therapy. Nature Publishing Group 2015-03-24 /pmc/articles/PMC4371107/ /pubmed/25800793 http://dx.doi.org/10.1038/srep09429 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Feng, Yingying Xu, Xiaojie Zhang, Yunjing Ding, Jianhua Wang, Yonggang Zhang, Xiaopeng Wu, Zhe Kang, Lei Liang, Yingchun Zhou, LiYing Song, Santai Zhao, Ke Ye, Qinong HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
title | HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
title_full | HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
title_fullStr | HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
title_full_unstemmed | HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
title_short | HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
title_sort | hpip is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371107/ https://www.ncbi.nlm.nih.gov/pubmed/25800793 http://dx.doi.org/10.1038/srep09429 |
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