Effects of sleep deprivation and aging on long-term and remote memory in mice

Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired me...

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Detalles Bibliográficos
Autores principales: Vecsey, Christopher G., Park, Alan J., Khatib, Nora, Abel, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371173/
https://www.ncbi.nlm.nih.gov/pubmed/25776037
http://dx.doi.org/10.1101/lm.036590.114
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author Vecsey, Christopher G.
Park, Alan J.
Khatib, Nora
Abel, Ted
author_facet Vecsey, Christopher G.
Park, Alan J.
Khatib, Nora
Abel, Ted
author_sort Vecsey, Christopher G.
collection PubMed
description Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.
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spelling pubmed-43711732016-04-01 Effects of sleep deprivation and aging on long-term and remote memory in mice Vecsey, Christopher G. Park, Alan J. Khatib, Nora Abel, Ted Learn Mem Brief Communication Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice. Cold Spring Harbor Laboratory Press 2015-04 /pmc/articles/PMC4371173/ /pubmed/25776037 http://dx.doi.org/10.1101/lm.036590.114 Text en © 2015 Vecsey et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Vecsey, Christopher G.
Park, Alan J.
Khatib, Nora
Abel, Ted
Effects of sleep deprivation and aging on long-term and remote memory in mice
title Effects of sleep deprivation and aging on long-term and remote memory in mice
title_full Effects of sleep deprivation and aging on long-term and remote memory in mice
title_fullStr Effects of sleep deprivation and aging on long-term and remote memory in mice
title_full_unstemmed Effects of sleep deprivation and aging on long-term and remote memory in mice
title_short Effects of sleep deprivation and aging on long-term and remote memory in mice
title_sort effects of sleep deprivation and aging on long-term and remote memory in mice
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371173/
https://www.ncbi.nlm.nih.gov/pubmed/25776037
http://dx.doi.org/10.1101/lm.036590.114
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