The hunt for origins of DNA replication in multicellular eukaryotes

Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that featu...

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Detalles Bibliográficos
Autores principales: Urban, John M., Foulk, Michael S., Casella, Cinzia, Gerbi, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371235/
https://www.ncbi.nlm.nih.gov/pubmed/25926981
http://dx.doi.org/10.12703/P7-30
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author Urban, John M.
Foulk, Michael S.
Casella, Cinzia
Gerbi, Susan A.
author_facet Urban, John M.
Foulk, Michael S.
Casella, Cinzia
Gerbi, Susan A.
author_sort Urban, John M.
collection PubMed
description Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed.
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spelling pubmed-43712352015-04-29 The hunt for origins of DNA replication in multicellular eukaryotes Urban, John M. Foulk, Michael S. Casella, Cinzia Gerbi, Susan A. F1000Prime Rep Review Article Origins of DNA replication (ORIs) occur at defined regions in the genome. Although DNA sequence defines the position of ORIs in budding yeast, the factors for ORI specification remain elusive in metazoa. Several methods have been used recently to map ORIs in metazoan genomes with the hope that features for ORI specification might emerge. These methods are reviewed here with analysis of their advantages and shortcomings. The various factors that may influence ORI selection for initiation of DNA replication are discussed. Faculty of 1000 Ltd 2015-03-03 /pmc/articles/PMC4371235/ /pubmed/25926981 http://dx.doi.org/10.12703/P7-30 Text en © 2015 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Urban, John M.
Foulk, Michael S.
Casella, Cinzia
Gerbi, Susan A.
The hunt for origins of DNA replication in multicellular eukaryotes
title The hunt for origins of DNA replication in multicellular eukaryotes
title_full The hunt for origins of DNA replication in multicellular eukaryotes
title_fullStr The hunt for origins of DNA replication in multicellular eukaryotes
title_full_unstemmed The hunt for origins of DNA replication in multicellular eukaryotes
title_short The hunt for origins of DNA replication in multicellular eukaryotes
title_sort hunt for origins of dna replication in multicellular eukaryotes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371235/
https://www.ncbi.nlm.nih.gov/pubmed/25926981
http://dx.doi.org/10.12703/P7-30
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