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Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis
OBJECTIVES: Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Epidemiology
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371392/ https://www.ncbi.nlm.nih.gov/pubmed/25687950 http://dx.doi.org/10.4178/epih/e2015005 |
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author | Bae, Jong-Myon |
author_facet | Bae, Jong-Myon |
author_sort | Bae, Jong-Myon |
collection | PubMed |
description | OBJECTIVES: Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues. Another meta-analysis of the related articles is needed to evaluate the potential link between HPV infection and PCa risk. METHODS: A snowballing search strategy was applied to the previously cited articles in the above-mentioned expert review and systematic review. Additional articles selected for this meta-analysis should fulfill all following inclusion criteria: (a) evaluation of detected HPV-16 DNA in tissue samples and the PCa risk and (b) report of the HPV-16 prevalence in both cancer and control tissues. Estimated summary odds ratios (sOR) with 95% confidence intervals (CI) were calculated using fixed effect or random-effect models. RESULTS: Hand searching identified 16 new articles. The sOR of the total 30 articles indicated a significant HPV-16 infection-related increase in the PCa risk (sOR, 1.851; 95% CI, 1.353 to 2.532, I(2)=37.82%). CONCLUSIONS: These facts provide additional supportive evidence for a causal role of HPV-16 infection in prostate carcinogenesis. As the PCa incidence rates have increased rapidly in Asian countries, including Korea, during the last several decades, further studies of HPV-related PCa carcinogenesis may be necessary. |
format | Online Article Text |
id | pubmed-4371392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Society of Epidemiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-43713922015-04-03 Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis Bae, Jong-Myon Epidemiol Health Review OBJECTIVES: Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues. Another meta-analysis of the related articles is needed to evaluate the potential link between HPV infection and PCa risk. METHODS: A snowballing search strategy was applied to the previously cited articles in the above-mentioned expert review and systematic review. Additional articles selected for this meta-analysis should fulfill all following inclusion criteria: (a) evaluation of detected HPV-16 DNA in tissue samples and the PCa risk and (b) report of the HPV-16 prevalence in both cancer and control tissues. Estimated summary odds ratios (sOR) with 95% confidence intervals (CI) were calculated using fixed effect or random-effect models. RESULTS: Hand searching identified 16 new articles. The sOR of the total 30 articles indicated a significant HPV-16 infection-related increase in the PCa risk (sOR, 1.851; 95% CI, 1.353 to 2.532, I(2)=37.82%). CONCLUSIONS: These facts provide additional supportive evidence for a causal role of HPV-16 infection in prostate carcinogenesis. As the PCa incidence rates have increased rapidly in Asian countries, including Korea, during the last several decades, further studies of HPV-related PCa carcinogenesis may be necessary. Korean Society of Epidemiology 2015-02-11 /pmc/articles/PMC4371392/ /pubmed/25687950 http://dx.doi.org/10.4178/epih/e2015005 Text en ©2015, Korean Society of Epidemiology This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Bae, Jong-Myon Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
title | Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
title_full | Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
title_fullStr | Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
title_full_unstemmed | Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
title_short | Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
title_sort | human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371392/ https://www.ncbi.nlm.nih.gov/pubmed/25687950 http://dx.doi.org/10.4178/epih/e2015005 |
work_keys_str_mv | AT baejongmyon humanpapillomavirus16infectionasapotentialriskfactorforprostatecanceranadaptivemetaanalysis |