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Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?

BACKGROUND: Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we investigated which VBM results may more represent atrophy by comparing with Fr...

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Autores principales: Rajagopalan, Venkateswaran, Pioro, Erik P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371611/
https://www.ncbi.nlm.nih.gov/pubmed/25879588
http://dx.doi.org/10.1186/s12883-015-0274-8
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author Rajagopalan, Venkateswaran
Pioro, Erik P
author_facet Rajagopalan, Venkateswaran
Pioro, Erik P
author_sort Rajagopalan, Venkateswaran
collection PubMed
description BACKGROUND: Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we investigated which VBM results may more represent atrophy by comparing with Freesurfer’s cortical volume and thickness measures. METHODS: MRI at 1.5 T was obtained during routine clinical imaging of ALS-FTD patients (n = 18) and in unaffected neurologic controls (n = 15). Gray matter (GM) VBM analysis was carried out using FSL and SPM. Cortical thickness and volume analysis was performed using Freesurfer. RESULTS: GM volume was significantly (p < 0.05) reduced in both motor and extra motor regions in ALS- FTD when compared to unaffected neurologic controls in FSL and Freesurfer but not in SPM. Dice similarity index for cortical GM volume changes between FSL and Freesurfer was 0.30 for motor and 0.31 for non-motor regions as opposed to 0 (motor) and 0.02 (non-motor) between SPM and Freesurfer. CONCLUSION: GM volume changes using FSL showed similar pattern with Freesurfer cortical volume and thickness changes in contrast to SPM results. Our results suggest that, at least for our dataset, VBM results obtained using FSL software should be considered as more representative of GM atrophy.
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spelling pubmed-43716112015-03-25 Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider? Rajagopalan, Venkateswaran Pioro, Erik P BMC Neurol Research Article BACKGROUND: Because our previous study showed disparate voxel based morphometry (VBM) results between SPM and FSL softwares in the brain of amyotrophic lateral sclerosis patients with frontotemporal dementia (ALS-FTD), we investigated which VBM results may more represent atrophy by comparing with Freesurfer’s cortical volume and thickness measures. METHODS: MRI at 1.5 T was obtained during routine clinical imaging of ALS-FTD patients (n = 18) and in unaffected neurologic controls (n = 15). Gray matter (GM) VBM analysis was carried out using FSL and SPM. Cortical thickness and volume analysis was performed using Freesurfer. RESULTS: GM volume was significantly (p < 0.05) reduced in both motor and extra motor regions in ALS- FTD when compared to unaffected neurologic controls in FSL and Freesurfer but not in SPM. Dice similarity index for cortical GM volume changes between FSL and Freesurfer was 0.30 for motor and 0.31 for non-motor regions as opposed to 0 (motor) and 0.02 (non-motor) between SPM and Freesurfer. CONCLUSION: GM volume changes using FSL showed similar pattern with Freesurfer cortical volume and thickness changes in contrast to SPM results. Our results suggest that, at least for our dataset, VBM results obtained using FSL software should be considered as more representative of GM atrophy. BioMed Central 2015-03-13 /pmc/articles/PMC4371611/ /pubmed/25879588 http://dx.doi.org/10.1186/s12883-015-0274-8 Text en © Rajagopalan and Pioro; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rajagopalan, Venkateswaran
Pioro, Erik P
Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?
title Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?
title_full Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?
title_fullStr Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?
title_full_unstemmed Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?
title_short Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: which VBM results to consider?
title_sort disparate voxel based morphometry (vbm) results between spm and fsl softwares in als patients with frontotemporal dementia: which vbm results to consider?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371611/
https://www.ncbi.nlm.nih.gov/pubmed/25879588
http://dx.doi.org/10.1186/s12883-015-0274-8
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