Discovery of a small molecule that inhibits bacterial ribosome biogenesis

While small molecule inhibitors of the bacterial ribosome have been instrumental in understanding protein translation, no such probes exist to study ribosome biogenesis. We screened a diverse chemical collection that included previously approved drugs for compounds that induced cold sensitive growth...

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Detalles Bibliográficos
Autores principales: Stokes, Jonathan M, Davis, Joseph H, Mangat, Chand S, Williamson, James R, Brown, Eric D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371806/
https://www.ncbi.nlm.nih.gov/pubmed/25233066
http://dx.doi.org/10.7554/eLife.03574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371806/
https://www.ncbi.nlm.nih.gov/pubmed/25233066
http://dx.doi.org/10.7554/eLife.03574

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