Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier

In vitro primary screening for identifying bioactive compounds (inhibitors, activators or pharmacological chaperones) against a protein target results in the discovery of lead compounds that must be tested in cell-based efficacy secondary screenings. Very often lead compounds do not succeed because...

Descripción completa

Detalles Bibliográficos
Autores principales: Claveria-Gimeno, Rafael, Vega, Sonia, Grazu, Valeria, de la Fuente, Jesús M, Lanas, Angel, Velazquez-Campoy, Adrian, Abian, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371900/
https://www.ncbi.nlm.nih.gov/pubmed/25834436
http://dx.doi.org/10.2147/IJN.S79480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371900/
https://www.ncbi.nlm.nih.gov/pubmed/25834436
http://dx.doi.org/10.2147/IJN.S79480

Ejemplares similares