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Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier
In vitro primary screening for identifying bioactive compounds (inhibitors, activators or pharmacological chaperones) against a protein target results in the discovery of lead compounds that must be tested in cell-based efficacy secondary screenings. Very often lead compounds do not succeed because...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371900/ https://www.ncbi.nlm.nih.gov/pubmed/25834436 http://dx.doi.org/10.2147/IJN.S79480 |