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Enzyme-Catalyzed Macrocyclization of Long Unprotected Peptides

[Image: see text] A glutathione S-transferase (GST) catalyzed macrocyclization reaction for peptides up to 40 amino acids in length is reported. GST catalyzes the selective S(N)Ar reaction between an N-terminal glutathione (GSH, γ-Glu-Cys-Gly) tag and a C-terminal perfluoroaryl-modified cysteine on...

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Detalles Bibliográficos
Autores principales:	Zhang, Chi, Dai, Peng, Spokoyny, Alexander M., Pentelute, Bradley L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372082/ https://www.ncbi.nlm.nih.gov/pubmed/25002256 http://dx.doi.org/10.1021/ol501609y

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