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Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor

[Image: see text] Development of isoform-selective histone deacetylase (HDAC) inhibitors is of great biological and medical interest. Among 11 zinc-dependent HDAC isoforms, it is particularly challenging to achieve isoform inhibition selectivity between HDAC1 and HDAC2 due to their very high structu...

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Detalles Bibliográficos
Autores principales:	Zhou, Jingwei, Li, Min, Chen, Nanhao, Wang, Shenglong, Luo, Hai-Bin, Zhang, Yingkai, Wu, Ruibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372102/ https://www.ncbi.nlm.nih.gov/pubmed/25546141 http://dx.doi.org/10.1021/cb500767c

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