The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation

p204 is a member of the interferon-inducible p200 family proteins in mice. The p200 family has been reported to be multifunctional regulators of cell proliferation, differentiation, apoptosis and senescence. Interferon-inducible protein 16 (IFI16) is regarded as the human ortholog of p204 in several...

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Autores principales: Zhao, Hua, Gonzalezgugel, Elena, Cheng, Lei, Richbourgh, Brendon, Nie, Lin, Liu, Chuanju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372153/
https://www.ncbi.nlm.nih.gov/pubmed/25815367
http://dx.doi.org/10.1016/j.gendis.2014.10.003
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author Zhao, Hua
Gonzalezgugel, Elena
Cheng, Lei
Richbourgh, Brendon
Nie, Lin
Liu, Chuanju
author_facet Zhao, Hua
Gonzalezgugel, Elena
Cheng, Lei
Richbourgh, Brendon
Nie, Lin
Liu, Chuanju
author_sort Zhao, Hua
collection PubMed
description p204 is a member of the interferon-inducible p200 family proteins in mice. The p200 family has been reported to be multifunctional regulators of cell proliferation, differentiation, apoptosis and senescence. Interferon-inducible protein 16 (IFI16) is regarded as the human ortholog of p204 in several studies. This is possibly due to the similarity of their structures. However the consistency of their functions is still elusive. Currently, an emerging focus has been placed upon the role of the p200 proteins as sensors for microbial DNA in innate immune responses and provides new insights into infections as well as autoimmune diseases. This review specially focuses on IFI16 and p204, the member of p200 family in human and murine respectively, and their pathophysiological roles in innate immune responses, cell differentiation and proliferation.
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spelling pubmed-43721532015-03-24 The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation Zhao, Hua Gonzalezgugel, Elena Cheng, Lei Richbourgh, Brendon Nie, Lin Liu, Chuanju Genes Dis Article p204 is a member of the interferon-inducible p200 family proteins in mice. The p200 family has been reported to be multifunctional regulators of cell proliferation, differentiation, apoptosis and senescence. Interferon-inducible protein 16 (IFI16) is regarded as the human ortholog of p204 in several studies. This is possibly due to the similarity of their structures. However the consistency of their functions is still elusive. Currently, an emerging focus has been placed upon the role of the p200 proteins as sensors for microbial DNA in innate immune responses and provides new insights into infections as well as autoimmune diseases. This review specially focuses on IFI16 and p204, the member of p200 family in human and murine respectively, and their pathophysiological roles in innate immune responses, cell differentiation and proliferation. Chongqing Medical University 2014-11-01 /pmc/articles/PMC4372153/ /pubmed/25815367 http://dx.doi.org/10.1016/j.gendis.2014.10.003 Text en Copyright © 2014, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Zhao, Hua
Gonzalezgugel, Elena
Cheng, Lei
Richbourgh, Brendon
Nie, Lin
Liu, Chuanju
The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
title The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
title_full The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
title_fullStr The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
title_full_unstemmed The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
title_short The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
title_sort roles of interferon-inducible p200 family members ifi16 and p204 in innate immune responses, cell differentiation and proliferation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372153/
https://www.ncbi.nlm.nih.gov/pubmed/25815367
http://dx.doi.org/10.1016/j.gendis.2014.10.003
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