Endosome traffic machinery meets the p53–p21 axis

SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK...

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Detalles Bibliográficos
Autores principales: Barroso-González, Jonathan, Thomas, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author'S View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372196/
https://www.ncbi.nlm.nih.gov/pubmed/25815376
http://dx.doi.org/10.4161/23723556.2014.975075
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author Barroso-González, Jonathan
Thomas, Gary
author_facet Barroso-González, Jonathan
Thomas, Gary
author_sort Barroso-González, Jonathan
collection PubMed
description SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK inhibitor p21 (CDKN1A) and induce cell cycle arrest.
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spelling pubmed-43721962015-03-24 Endosome traffic machinery meets the p53–p21 axis Barroso-González, Jonathan Thomas, Gary Mol Cell Oncol Author'S View SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK inhibitor p21 (CDKN1A) and induce cell cycle arrest. Taylor & Francis 2014-12-01 /pmc/articles/PMC4372196/ /pubmed/25815376 http://dx.doi.org/10.4161/23723556.2014.975075 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author'S View
Barroso-González, Jonathan
Thomas, Gary
Endosome traffic machinery meets the p53–p21 axis
title Endosome traffic machinery meets the p53–p21 axis
title_full Endosome traffic machinery meets the p53–p21 axis
title_fullStr Endosome traffic machinery meets the p53–p21 axis
title_full_unstemmed Endosome traffic machinery meets the p53–p21 axis
title_short Endosome traffic machinery meets the p53–p21 axis
title_sort endosome traffic machinery meets the p53–p21 axis
topic Author'S View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372196/
https://www.ncbi.nlm.nih.gov/pubmed/25815376
http://dx.doi.org/10.4161/23723556.2014.975075
work_keys_str_mv AT barrosogonzalezjonathan endosometrafficmachinerymeetsthep53p21axis
AT thomasgary endosometrafficmachinerymeetsthep53p21axis

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