Cargando…

Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity

Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC) strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruan, Xiaosai, Sack, David A., Zhang, Weiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372207/ https://www.ncbi.nlm.nih.gov/pubmed/25803825 http://dx.doi.org/10.1371/journal.pone.0121623

Ejemplares similares

Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC)
por: Rausch, Dana, et al.
Publicado: (2017)

Erratum to “Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC)” [Vet. Microbiol. 202 (2017) 79–89]
por: Rausch, Dana, et al.
Publicado: (2018)

Co-administered Tag-Less Toxoid Fusion 3xSTa(N12S)-mnLT(R192G/L211A) and CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) Induce Neutralizing Antibodies to 7 Adhesins (CFA/I, CS1-CS6) and Both Enterotoxins (LT, STa) of Enterotoxigenic Escherichia coli (ETEC)
por: Duan, Qiangde, et al.
Publicado: (2018)

Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6)
por: Seo, Hyesuk, et al.
Publicado: (2019)

MEFA (multiepitope fusion antigen)-Novel Technology for Structural Vaccinology, Proof from Computational and Empirical Immunogenicity Characterization of an Enterotoxigenic Escherichia coli (ETEC) Adhesin MEFA
por: Duan, Qiangde, et al.
Publicado: (2017)

The LT1 and LT2 variants of the enterotoxigenic Escherichia coli (ETEC) heat-labile toxin (LT) are associated with major ETEC lineages
por: Joffré, Enrique, et al.
Publicado: (2016)

Modified Heat-Stable Toxins (hSTa) of Enterotoxigenic Escherichia coli Lose Toxicity but Display Antigenicity after Being Genetically Fused to Heat-Labile Toxoid LT(R192G)
por: Liu, Mei, et al.
Publicado: (2011)

Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC)
por: Norton, Elizabeth B., et al.
Publicado: (2015)

Correction: Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC)
Publicado: (2015)

A Polyvalent Adhesin–Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Escherichia coli Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)
por: Li, Siqi, et al.
Publicado: (2023)

Biochemical and immunological characterization of an ETEC CFA/I adhesin cholera toxin B subunit chimera
por: Jobling, Michael G., et al.
Publicado: (2020)

Alkaline pH Is a Signal for Optimal Production and Secretion of the Heat Labile Toxin, LT in Enterotoxigenic Escherichia Coli (ETEC)
por: Gonzales, Lucia, et al.
Publicado: (2013)

The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model
por: Smith, Emily M., et al.
Publicado: (2022)

Toxicity and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile and Heat-Stable Toxoid Fusion 3xSTa(A14Q)-LT(S63K/R192G/L211A) in a Murine Model
por: Zhang, Chengxian, et al.
Publicado: (2013)

Expression of proteins Heat-Labile (Lt-1) and Heat-Stable (STa) Escherichia coli expression of proteins Heat-Labile (Lt-1) and Heat-Stable (STa) Escherichia coli
por: Cavalcante, Alessandra, et al.
Publicado: (2014)

A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G)
por: Gutiérrez, Ramiro L., et al.
Publicado: (2023)

Crystallization and preliminary X-ray diffraction analyses of several forms of the CfaB major subunit of enterotoxigenic Escherichia coli CFA/I fimbriae
por: Li, Yong-Fu, et al.
Publicado: (2009)

Biofilm formation and binding specificities of CFA/I, CFA/II and CS2 adhesions of enterotoxigenic Escherichia coli and Cfae-R181A mutant
por: Liaqat, Iram, et al.
Publicado: (2012)

Heat-Stable Enterotoxin Secretions Assessed via ICP-MS Reveal Iron-Mediated Regulation of Virulence in CFA/I- and CS6-Expressing ETEC Isolates
por: Hollifield, Ian E., et al.
Publicado: (2023)

Using iMCFA to Perform the CFA, Multilevel CFA, and Maximum Model for Analyzing Complex Survey Data
por: Wu, Jiun-Yu, et al.
Publicado: (2018)

Anti-Toxin Responses to Natural Enterotoxigenic Escherichia coli (ETEC) Infection in Adults and Children in Bangladesh
por: Girardi, Petra, et al.
Publicado: (2023)

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge
por: Harro, Clayton, et al.
Publicado: (2019)

Identification of the Bartonella autotransporter CFA as a protective antigen and hypervariable target of neutralizing antibodies in mice
por: Siewert, Lena K., et al.
Publicado: (2022)

Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
por: Zegeye, Ephrem Debebe, et al.
Publicado: (2018)

CFA Program Curriculum 2018 Level II
por: Collective
Publicado: (2017)

Speed Effect Analysis Using the CFA Framework
por: Schweizer, Karl, et al.
Publicado: (2019)

The role of cfa gene in ampicillin tolerance in Shigella
por: Liu, Qiaoli, et al.
Publicado: (2019)

Control of Virulence Gene Expression by the Master Regulator, CfaD, in the Prototypical Enterotoxigenic Escherichia coli Strain, H10407
por: Hodson, Carla, et al.
Publicado: (2017)

The effects of Escherichia coli STa (heat stable) toxin on the contractility of isolated human myometrium in vitro.
por: de Carrera, A L, et al.
Publicado: (1998)

Draft Genome Sequence of an Enterotoxigenic Escherichia coli Strain Carrying Genes for Colonization Surface Antigen 13 and a Heat-Labile Toxin
por: Njoroge, Samuel M., et al.
Publicado: (2022)

Cryo-EM structure of the CFA/I pilus rod
por: Zheng, Weili, et al.
Publicado: (2019)

On Modeling Missing Data of an Incomplete Design in the CFA Framework
por: Schweizer, Karl, et al.
Publicado: (2020)

Compression for Bayer CFA Images: Review and Performance Comparison
por: Chung, Kuo-Liang, et al.
Publicado: (2022)

Intradermal Administration of the Type II Heat-Labile Enterotoxins LT-IIb and LT-IIc of Enterotoxigenic Escherichia coli Enhances Humoral and CD8(+) T Cell Immunity to a Co-Administered Antigen
por: Hu, John C., et al.
Publicado: (2014)

Parenteral Adjuvant Effects of an Enterotoxigenic Escherichia coli Natural Heat-Labile Toxin Variant
por: Braga, Catarina J. M., et al.
Publicado: (2014)

Review of Newly Identified Functions Associated With the Heat-Labile Toxin of Enterotoxigenic Escherichia coli
por: Duan, Qiangde, et al.
Publicado: (2019)

Vaccine Candidate Double Mutant Variants of Enterotoxigenic Escherichia coli Heat-Stable Toxin
por: Zegeye, Ephrem Debebe, et al.
Publicado: (2022)

THE IMMUNOCHEMISTRY OF TOXINS AND TOXOIDS : VI. THE CRYSTALLIZATION AND CHARACTERIZATION OF TETANAL TOXIN
por: Pillemer, Louis, et al.
Publicado: (1948)

Molecular Characterization and Comparative Genomics of Clinical Hybrid Shiga Toxin-Producing and Enterotoxigenic Escherichia coli (STEC/ETEC) Strains in Sweden
por: Bai, Xiangning, et al.
Publicado: (2019)

Noise Reduction for CFA Image Sensors Exploiting HVS Behaviour
por: Bosco, Angelo, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_dsdsp9lvaavama3fnp7n779fih