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Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria

Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of...

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Detalles Bibliográficos
Autores principales:	Boyle, Michelle J., Reiling, Linda, Feng, Gaoqian, Langer, Christine, Osier, Faith H., Aspeling-Jones, Harvey, Cheng, Yik Sheng, Stubbs, Janine, Tetteh, Kevin K.A., Conway, David J., McCarthy, James S., Muller, Ivo, Marsh, Kevin, Anders, Robin F., Beeson, James G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372259/ https://www.ncbi.nlm.nih.gov/pubmed/25786180 http://dx.doi.org/10.1016/j.immuni.2015.02.012

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