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Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule
There are no accurate data on the diagnostic value of preoperative flexible bronchoscopy (FB) for persistent ground-glass nodule (GGN) of the lung. We evaluated the value of preoperative FB in patients with suspected GGN-type lung cancer. We retrospectively searched a database for subjects who had ‘...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372530/ https://www.ncbi.nlm.nih.gov/pubmed/25803430 http://dx.doi.org/10.1371/journal.pone.0121250 |
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author | Jhun, Byung Woo Um, Sang-Won Suh, Gee Young Chung, Man Pyo Kim, Hojoong Kwon, O Jung Lee, Kyung Soo Han, Joungho Kim, Jhingook |
author_facet | Jhun, Byung Woo Um, Sang-Won Suh, Gee Young Chung, Man Pyo Kim, Hojoong Kwon, O Jung Lee, Kyung Soo Han, Joungho Kim, Jhingook |
author_sort | Jhun, Byung Woo |
collection | PubMed |
description | There are no accurate data on the diagnostic value of preoperative flexible bronchoscopy (FB) for persistent ground-glass nodule (GGN) of the lung. We evaluated the value of preoperative FB in patients with suspected GGN-type lung cancer. We retrospectively searched a database for subjects who had ‘ground-glass opacity’, ‘non-solid nodule’, ‘part-solid nodule’, or ‘sub-solid nodule’ on chest computed tomography reports between February 2004 and March 2012. Patients who had infiltrative ground-glass opacity lesions, mediastinal lymphadenopathy, or pleural effusion, focal ground-glass opacity lesions >3 cm, and were lost to follow-up were excluded. We assessed the diagnostic value of preoperative FB in patients with persistent GGNs who underwent surgical resection. In total, 296 GGNs were evaluated by FB in 264 patients with persistent GGNs who underwent preoperative FB and surgical resection. The median size of the GGNs was 18 mm; 135 (46%) were pure GGN and 161 (54%) were part-solid GGN. No visible tumor or unsuspected endobronchial metastasis was identified by preoperative FB. Only 3 (1%, 3/208) GGNs were identified preoperatively as malignant by bronchial washing cytology; all were part-solid GGNs. No other etiology was identified by FB. Of the GGNs, 271 (91%) were subsequently confirmed as malignant and 25 (9%) were confirmed as benign at surgical resection. Consequently, the overall diagnostic sensitivity and negative predictive value of preoperative FB on a per-nodule basis was 1% (3/271) and 8% (25/293), respectively. The preoperative FB did not change the surgical strategy. Preoperative FB did not add much to the evaluation of persistent GGNs of the lung. Routine preoperative FB may have limited value in surgical candidates with small persistent pure GGNs. |
format | Online Article Text |
id | pubmed-4372530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43725302015-04-04 Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule Jhun, Byung Woo Um, Sang-Won Suh, Gee Young Chung, Man Pyo Kim, Hojoong Kwon, O Jung Lee, Kyung Soo Han, Joungho Kim, Jhingook PLoS One Research Article There are no accurate data on the diagnostic value of preoperative flexible bronchoscopy (FB) for persistent ground-glass nodule (GGN) of the lung. We evaluated the value of preoperative FB in patients with suspected GGN-type lung cancer. We retrospectively searched a database for subjects who had ‘ground-glass opacity’, ‘non-solid nodule’, ‘part-solid nodule’, or ‘sub-solid nodule’ on chest computed tomography reports between February 2004 and March 2012. Patients who had infiltrative ground-glass opacity lesions, mediastinal lymphadenopathy, or pleural effusion, focal ground-glass opacity lesions >3 cm, and were lost to follow-up were excluded. We assessed the diagnostic value of preoperative FB in patients with persistent GGNs who underwent surgical resection. In total, 296 GGNs were evaluated by FB in 264 patients with persistent GGNs who underwent preoperative FB and surgical resection. The median size of the GGNs was 18 mm; 135 (46%) were pure GGN and 161 (54%) were part-solid GGN. No visible tumor or unsuspected endobronchial metastasis was identified by preoperative FB. Only 3 (1%, 3/208) GGNs were identified preoperatively as malignant by bronchial washing cytology; all were part-solid GGNs. No other etiology was identified by FB. Of the GGNs, 271 (91%) were subsequently confirmed as malignant and 25 (9%) were confirmed as benign at surgical resection. Consequently, the overall diagnostic sensitivity and negative predictive value of preoperative FB on a per-nodule basis was 1% (3/271) and 8% (25/293), respectively. The preoperative FB did not change the surgical strategy. Preoperative FB did not add much to the evaluation of persistent GGNs of the lung. Routine preoperative FB may have limited value in surgical candidates with small persistent pure GGNs. Public Library of Science 2015-03-24 /pmc/articles/PMC4372530/ /pubmed/25803430 http://dx.doi.org/10.1371/journal.pone.0121250 Text en © 2015 Jhun et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Jhun, Byung Woo Um, Sang-Won Suh, Gee Young Chung, Man Pyo Kim, Hojoong Kwon, O Jung Lee, Kyung Soo Han, Joungho Kim, Jhingook Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule |
title | Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule |
title_full | Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule |
title_fullStr | Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule |
title_full_unstemmed | Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule |
title_short | Preoperative Flexible Bronchoscopy in Patients with Persistent Ground-Glass Nodule |
title_sort | preoperative flexible bronchoscopy in patients with persistent ground-glass nodule |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372530/ https://www.ncbi.nlm.nih.gov/pubmed/25803430 http://dx.doi.org/10.1371/journal.pone.0121250 |
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