Smad4 Loss Synergizes with TGFα Overexpression in Promoting Pancreatic Metaplasia, PanIN Development, and Fibrosis

AIMS: While overexpression of TGFα has been reported in human pancreatic ductal adenocarcinoma (PDAC), mice with overexpressed TGFα develop premalignant pancreatic acinar-to-ductal metaplasia (ADM) but not PDAC. TGF-β signaling pathway is pivotal to the development of PDAC and tissue fibrosis. Here...

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Detalles Bibliográficos
Autores principales: Garcia-Carracedo, Dario, Yu, Chih-Chieh, Akhavan, Nathan, Fine, Stuart A., Schönleben, Frank, Maehara, Naoki, Karg, Dillon C., Xie, Chuangao, Qiu, Wanglong, Fine, Robert L., Remotti, Helen E., Su, Gloria H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372593/
https://www.ncbi.nlm.nih.gov/pubmed/25803032
http://dx.doi.org/10.1371/journal.pone.0120851

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