Cargando…
Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy
OBJECTIVES: Many previous studies have suggested that the outcome of prostate cancer (PCa) may be closely related to abnormal lipid metabolism. Therefore, in this study, we evaluated the preoperative lipid profiles of patients with clinically localized prostate cancer (PCa) who underwent radical pro...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372604/ https://www.ncbi.nlm.nih.gov/pubmed/25803284 http://dx.doi.org/10.1371/journal.pone.0122438 |
_version_ | 1782363209368338432 |
---|---|
author | Kang, Minyong Jeong, Chang Wook Ku, Ja Hyeon Kwak, Choel Kim, Hyeon Hoe |
author_facet | Kang, Minyong Jeong, Chang Wook Ku, Ja Hyeon Kwak, Choel Kim, Hyeon Hoe |
author_sort | Kang, Minyong |
collection | PubMed |
description | OBJECTIVES: Many previous studies have suggested that the outcome of prostate cancer (PCa) may be closely related to abnormal lipid metabolism. Therefore, in this study, we evaluated the preoperative lipid profiles of patients with clinically localized prostate cancer (PCa) who underwent radical prostatectomy (RP), with particular emphasis on the relationship between these profiles and biochemical recurrence (BCR). PATIENTS AND METHODS: We evaluated 715 consecutive men with clinically localized PCa who underwent RP at our institution between January 2011 and December 2013. We defined hypertriglyceridemia as a fasting serum triglyceride (TG) level greater than 200 mg/dL. We used the Kaplan—Meier method to predict BCR-free survival and applied the log-rank test to determine the statistical significance between survival curves. Cox proportional hazard ratio (HR) models were used to identify the significant predictors of BCR according to clinicopathological variables. RESULTS: Of 663 patients who underwent RP for clinically localized PCa, 66 (10.0%) showed BCR during a median follow-up period of 21 months. Patients without BCR had higher levels of serum TG, and patients with hypertriglyceridemia were significantly more likely to achieve BCR-free survival in the Kaplan—Meier analysis (log-rank test, P = 0.009). In the multivariable analysis, the presence of hypertriglyceridemia (HR 0.22), pathologic Gleason score (≥8; HR 2.85), pathologic T stage (≥pT3; HR 3.44), and a positive surgical margin (HR, 2.39) were still significant BCR predictors. CONCLUSIONS: We found that preoperative hypertriglyceridemia was associated with a lower risk of BCR after RP in patients with clinically localized PCa. Our results could help to clarify the currently conflicting evidence on the relationship between serum lipid profiles, particularly the presence of hypertriglyceridemia, and the risk of BCR in PC a patients after surgery. |
format | Online Article Text |
id | pubmed-4372604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43726042015-04-04 Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy Kang, Minyong Jeong, Chang Wook Ku, Ja Hyeon Kwak, Choel Kim, Hyeon Hoe PLoS One Research Article OBJECTIVES: Many previous studies have suggested that the outcome of prostate cancer (PCa) may be closely related to abnormal lipid metabolism. Therefore, in this study, we evaluated the preoperative lipid profiles of patients with clinically localized prostate cancer (PCa) who underwent radical prostatectomy (RP), with particular emphasis on the relationship between these profiles and biochemical recurrence (BCR). PATIENTS AND METHODS: We evaluated 715 consecutive men with clinically localized PCa who underwent RP at our institution between January 2011 and December 2013. We defined hypertriglyceridemia as a fasting serum triglyceride (TG) level greater than 200 mg/dL. We used the Kaplan—Meier method to predict BCR-free survival and applied the log-rank test to determine the statistical significance between survival curves. Cox proportional hazard ratio (HR) models were used to identify the significant predictors of BCR according to clinicopathological variables. RESULTS: Of 663 patients who underwent RP for clinically localized PCa, 66 (10.0%) showed BCR during a median follow-up period of 21 months. Patients without BCR had higher levels of serum TG, and patients with hypertriglyceridemia were significantly more likely to achieve BCR-free survival in the Kaplan—Meier analysis (log-rank test, P = 0.009). In the multivariable analysis, the presence of hypertriglyceridemia (HR 0.22), pathologic Gleason score (≥8; HR 2.85), pathologic T stage (≥pT3; HR 3.44), and a positive surgical margin (HR, 2.39) were still significant BCR predictors. CONCLUSIONS: We found that preoperative hypertriglyceridemia was associated with a lower risk of BCR after RP in patients with clinically localized PCa. Our results could help to clarify the currently conflicting evidence on the relationship between serum lipid profiles, particularly the presence of hypertriglyceridemia, and the risk of BCR in PC a patients after surgery. Public Library of Science 2015-03-24 /pmc/articles/PMC4372604/ /pubmed/25803284 http://dx.doi.org/10.1371/journal.pone.0122438 Text en © 2015 Kang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kang, Minyong Jeong, Chang Wook Ku, Ja Hyeon Kwak, Choel Kim, Hyeon Hoe Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy |
title | Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy |
title_full | Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy |
title_fullStr | Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy |
title_full_unstemmed | Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy |
title_short | Hypertriglyceridemia Is a Potential Preoperative Predictor for Biochemical Recurrence after Radical Prostatectomy |
title_sort | hypertriglyceridemia is a potential preoperative predictor for biochemical recurrence after radical prostatectomy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372604/ https://www.ncbi.nlm.nih.gov/pubmed/25803284 http://dx.doi.org/10.1371/journal.pone.0122438 |
work_keys_str_mv | AT kangminyong hypertriglyceridemiaisapotentialpreoperativepredictorforbiochemicalrecurrenceafterradicalprostatectomy AT jeongchangwook hypertriglyceridemiaisapotentialpreoperativepredictorforbiochemicalrecurrenceafterradicalprostatectomy AT kujahyeon hypertriglyceridemiaisapotentialpreoperativepredictorforbiochemicalrecurrenceafterradicalprostatectomy AT kwakchoel hypertriglyceridemiaisapotentialpreoperativepredictorforbiochemicalrecurrenceafterradicalprostatectomy AT kimhyeonhoe hypertriglyceridemiaisapotentialpreoperativepredictorforbiochemicalrecurrenceafterradicalprostatectomy |