Cargando…

Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients

Protein-energy wasting is highly prevalent in hemodialysis patients, and it contributes to patient morbidity and mortality. The ubiquitin-proteasome system is the major pathway for intracellular protein degradation and it is involved in the regulation of basic cellular processes. However, the role o...

Descripción completa

Detalles Bibliográficos
Autores principales: Fukasawa, Hirotaka, Kaneko, Mai, Niwa, Hiroki, Matsuyama, Takashi, Yasuda, Hideo, Kumagai, Hiromichi, Furuya, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372611/
https://www.ncbi.nlm.nih.gov/pubmed/25803510
http://dx.doi.org/10.1371/journal.pone.0121352
_version_ 1782363210740924416
author Fukasawa, Hirotaka
Kaneko, Mai
Niwa, Hiroki
Matsuyama, Takashi
Yasuda, Hideo
Kumagai, Hiromichi
Furuya, Ryuichi
author_facet Fukasawa, Hirotaka
Kaneko, Mai
Niwa, Hiroki
Matsuyama, Takashi
Yasuda, Hideo
Kumagai, Hiromichi
Furuya, Ryuichi
author_sort Fukasawa, Hirotaka
collection PubMed
description Protein-energy wasting is highly prevalent in hemodialysis patients, and it contributes to patient morbidity and mortality. The ubiquitin-proteasome system is the major pathway for intracellular protein degradation and it is involved in the regulation of basic cellular processes. However, the role of this system in the determination of nutritional status is largely unknown. To examine a relationship between protein-energy wasting and the ubiquitin-proteasome system, a cross-sectional study of 76 hemodialysis patients was performed. Plasma concentrations of 20S proteasome were studied to evaluate its association with muscle and fat mass, which were investigated by abdominal muscle and fat areas measured using computed tomography and by creatinine production estimated using the creatinine kinetic model. Plasma 20S proteasome concentrations significantly and negatively correlated with abdominal muscle areas and creatinine production (rho = -0.263, P < 0.05 and rho = -0.241, P < 0.05, respectively), but not abdominal subcutaneous and visceral fat areas. Multiple regression analyses showed that 20S proteasome was a significant independent predictor of abdominal muscle area (P < 0.05). In conclusion, plasma 20S proteasome concentrations were independently associated with abdominal muscle mass in hemodialysis patients. Our findings indicate a relationship between circulating 20S proteasomes and muscle metabolism in these patients. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000012341
format Online
Article
Text
id pubmed-4372611
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-43726112015-04-04 Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients Fukasawa, Hirotaka Kaneko, Mai Niwa, Hiroki Matsuyama, Takashi Yasuda, Hideo Kumagai, Hiromichi Furuya, Ryuichi PLoS One Research Article Protein-energy wasting is highly prevalent in hemodialysis patients, and it contributes to patient morbidity and mortality. The ubiquitin-proteasome system is the major pathway for intracellular protein degradation and it is involved in the regulation of basic cellular processes. However, the role of this system in the determination of nutritional status is largely unknown. To examine a relationship between protein-energy wasting and the ubiquitin-proteasome system, a cross-sectional study of 76 hemodialysis patients was performed. Plasma concentrations of 20S proteasome were studied to evaluate its association with muscle and fat mass, which were investigated by abdominal muscle and fat areas measured using computed tomography and by creatinine production estimated using the creatinine kinetic model. Plasma 20S proteasome concentrations significantly and negatively correlated with abdominal muscle areas and creatinine production (rho = -0.263, P < 0.05 and rho = -0.241, P < 0.05, respectively), but not abdominal subcutaneous and visceral fat areas. Multiple regression analyses showed that 20S proteasome was a significant independent predictor of abdominal muscle area (P < 0.05). In conclusion, plasma 20S proteasome concentrations were independently associated with abdominal muscle mass in hemodialysis patients. Our findings indicate a relationship between circulating 20S proteasomes and muscle metabolism in these patients. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000012341 Public Library of Science 2015-03-24 /pmc/articles/PMC4372611/ /pubmed/25803510 http://dx.doi.org/10.1371/journal.pone.0121352 Text en © 2015 Fukasawa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Fukasawa, Hirotaka
Kaneko, Mai
Niwa, Hiroki
Matsuyama, Takashi
Yasuda, Hideo
Kumagai, Hiromichi
Furuya, Ryuichi
Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients
title Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients
title_full Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients
title_fullStr Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients
title_full_unstemmed Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients
title_short Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients
title_sort circulating 20s proteasome is independently associated with abdominal muscle mass in hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372611/
https://www.ncbi.nlm.nih.gov/pubmed/25803510
http://dx.doi.org/10.1371/journal.pone.0121352
work_keys_str_mv AT fukasawahirotaka circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients
AT kanekomai circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients
AT niwahiroki circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients
AT matsuyamatakashi circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients
AT yasudahideo circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients
AT kumagaihiromichi circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients
AT furuyaryuichi circulating20sproteasomeisindependentlyassociatedwithabdominalmusclemassinhemodialysispatients