JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth()()

Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 has been implicated in cell proliferation and survival of many cancers including head and neck squamous cell carcinoma (HNSCC). AZD1480, an orally active pharmacologic inhibitor of JAK1/JAK2, has...

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Detalles Bibliográficos
Autores principales: Sen, Malabika, Pollock, Netanya I., Black, John, DeGrave, Kara A., Wheeler, Sarah, Freilino, Maria L., Joyce, Sonali, Lui, Vivian W.Y., Zeng, Yan, Chiosea, Simion I., Grandis, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372647/
https://www.ncbi.nlm.nih.gov/pubmed/25810010
http://dx.doi.org/10.1016/j.neo.2015.01.003

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