Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β(2)-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis

Objective. IgG aPL against domain I of β(2)-glycoprotein I (β(2)GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG aDI in vivo. In this proof-of-...

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Detalles Bibliográficos
Autores principales: Pericleous, Charis, Ruiz-Limón, Patricia, Romay-Penabad, Zurina, Marín, Ana Carrera, Garza-Garcia, Acely, Murfitt, Lucy, Driscoll, Paul C., Latchman, David S., Isenberg, David A., Giles, Ian, Ioannou, Yiannis, Rahman, Anisur, Pierangeli, Silvia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Basic and Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372675/
https://www.ncbi.nlm.nih.gov/pubmed/25273993
http://dx.doi.org/10.1093/rheumatology/keu360

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