Cargando…

Ligustrazinyl amides: a novel class of ligustrazine-phenolic acid derivatives with neuroprotective effects

BACKGROUND: Ligustrazine has potent effects of thrombolysis, neuroprotection and vascular protection, which were important for effectively protecting the nervous system. Previous study in our laboratory reported that ligustrazine-benzoic acid derivatives have been shown to exhibit beneficial effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Guoliang, Xu, Xin, Xu, Kuo, Chu, Fuhao, Song, Jixiang, Zhou, Shen, Xu, Bing, Gong, Yan, Zhang, Huazheng, Zhang, Yuzhong, Wang, Penglong, Lei, Haimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372684/ https://www.ncbi.nlm.nih.gov/pubmed/25810760 http://dx.doi.org/10.1186/s13065-015-0084-5

Ejemplares similares

Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents
por: Chu, Fuhao, et al.
Publicado: (2014)

Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells
por: Bi, Siling, et al.
Publicado: (2016)

A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation
por: Xu, Bing, et al.
Publicado: (2015)

A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-κB/p65 and COX-2 Expression on Human Hepatoma Cells. Part 3
por: Zhang, Chenze, et al.
Publicado: (2015)

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
por: Wang, Penglong, et al.
Publicado: (2013)

Novel Neuroprotective Lead Compound Ligustrazine Derivative Mass Spectrometry Fragmentation Rule and Metabolites in Rats by LC/LTQ-Orbitrap MS
por: Zhang, Xinyu, et al.
Publicado: (2018)

Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl(2)-induced neurotoxicity in differentiated PC12 cells
por: Xu, Bing, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents
por: Wang, Penglong, et al.
Publicado: (2012)

Correction: Li, G., et al. A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats. Int. J. Mol. Sci. 2015, 16, 21759–21774
por: Li, Guoliang, et al.
Publicado: (2016)

A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats
por: Li, Guoling, et al.
Publicado: (2015)

New Synthesis Method for Sultone Derivatives: Synthesis, Crystal Structure and Biological Evaluation of S-CA
por: Li, Bi, et al.
Publicado: (2015)

Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents
por: Guo, Wenbo, et al.
Publicado: (2016)

A New Oleanolic Acid Derivative against CCl(4)-Induced Hepatic Fibrosis in Rats
por: Xiang, Hongjun, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents
por: Wang, Hui, et al.
Publicado: (2018)

A Series of Oleanolic Acid Derivatives as Anti-Hepatitis B Virus Agents: Design, Synthesis, and in Vitro and in Vivo Biological Evaluation
por: Yan, Wenqiang, et al.
Publicado: (2016)

Compositions, Formation Mechanism, and Neuroprotective Effect of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang
por: Zhang, Chenze, et al.
Publicado: (2016)

Synergic Effect of Borneol and Ligustrazine on the Neuroprotection in Global Cerebral Ischemia/Reperfusion Injury: A Region-Specificity Study
por: Yu, Bin, et al.
Publicado: (2016)

BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation
por: Cui, Herong, et al.
Publicado: (2019)

Correction: Cui, H., et al. BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation. Int. J. Mol. Sci. 2019, 20, 4062
por: Cui, Herong, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis
por: Cai, Desheng, et al.
Publicado: (2019)

Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo
por: Liu, Xingyan, et al.
Publicado: (2011)

Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo
por: Chu, Fuhao, et al.
Publicado: (2018)

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats
por: Liu, Dandan, et al.
Publicado: (2023)

Novel Homo-Bivalent and Polyvalent Compounds Based on Ligustrazine and Heterocyclic Ring as Anticancer Agents
por: Wang, Jiawen, et al.
Publicado: (2019)

Impact of nonsteroidal aromatase inhibitors on steroid profile in a Chinese population
por: Xing, Yanyi, et al.
Publicado: (2017)

Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages
por: Jiang, Rundong, et al.
Publicado: (2021)

Effect of Ligustrazine on Endometrium Injury of Thin Endometrium Rats
por: Ye, Qing, et al.
Publicado: (2019)

Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents
por: Ma, Shitang, et al.
Publicado: (2022)

Ligustrazine Inhibits the Migration and Invasion of Renal Cell Carcinoma
por: Zhang, Xufeng, et al.
Publicado: (2023)

Synthesis of Novel Baicalein Amino Acid Derivatives and Biological Evaluation as Neuroprotective Agents
por: Jia, Xiaohui, et al.
Publicado: (2019)

Synergistic Effect of Berberine-Based Chinese Medicine Assembled Nanostructures on Diarrhea-Predominant Irritable Bowel Syndrome In Vivo
por: Li, Lei, et al.
Publicado: (2020)

Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia
por: Xu, Kuo, et al.
Publicado: (2013)

Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction
por: Yu, Tian, et al.
Publicado: (2016)

Therapeutic Effect of External Application of Ligustrazine Combined with Holistic Nursing on Pressure Sores
por: Niu, Junzhi, et al.
Publicado: (2016)

Ligustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1
por: Liu, Shufen, et al.
Publicado: (2016)

Combination of ferulic acid, ligustrazine and tetrahydropalmatine inhibits invasion and metastasis through MMP/TIMP signaling in endometriosis
por: Tan, Yi, et al.
Publicado: (2021)

Ligustrazine monomer against cerebral ischemia/reperfusion injury
por: Gao, Hai-jun, et al.
Publicado: (2015)

Ligustrazine inhibits the viability and motility of colon cancer cells
por: Chen, Xiaochao, et al.
Publicado: (2020)

Bioactive Phenolic Amides from Celtisafricana
por: Al-Taweel, Areej Mohammad, et al.
Publicado: (2012)

The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum
por: Zhu, Pei-Feng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gom3svvet8ug9nrdfhbc1sk6cl