Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders

The proinflammatory cytokine osteopontin (OPN) is elevated in the cerebrospinal fluid (CSF) in individuals with HIV-associated neurocognitive disorders (HAND) and remains so in those on suppressive antiretroviral therapy. To understand the pathophysiological significance of elevated OPN in the CNS,...

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Detalles Bibliográficos
Autores principales: Silva, Katie, Hope-Lucas, Calixto, White, Tyesha, Hairston, Tai-Kyung, Rameau, Tatenda, Brown, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372685/
https://www.ncbi.nlm.nih.gov/pubmed/25636782
http://dx.doi.org/10.1007/s13365-015-0317-3

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