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A microfluidic device based on an evaporation-driven micropump

In this paper we introduce a microfluidic device ultimately to be applied as a wearable sweat sensor. We show proof-of-principle of the microfluidic functions of the device, namely fluid collection and continuous fluid flow pumping. A filter-paper based layer, that eventually will form the interface...

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Autores principales: Nie, Chuan, Frijns, Arjan J. H., Mandamparambil, Rajesh, den Toonder, Jaap M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372687/
https://www.ncbi.nlm.nih.gov/pubmed/25804609
http://dx.doi.org/10.1007/s10544-015-9948-7
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author Nie, Chuan
Frijns, Arjan J. H.
Mandamparambil, Rajesh
den Toonder, Jaap M. J.
author_facet Nie, Chuan
Frijns, Arjan J. H.
Mandamparambil, Rajesh
den Toonder, Jaap M. J.
author_sort Nie, Chuan
collection PubMed
description In this paper we introduce a microfluidic device ultimately to be applied as a wearable sweat sensor. We show proof-of-principle of the microfluidic functions of the device, namely fluid collection and continuous fluid flow pumping. A filter-paper based layer, that eventually will form the interface between the device and the skin, is used to collect the fluid (e.g., sweat) and enter this into the microfluidic device. A controllable evaporation driven pump is used to drive a continuous fluid flow through a microfluidic channel and over a sensing area. The key element of the pump is a micro-porous membrane mounted at the channel outlet, such that a pore array with a regular hexagonal arrangement is realized through which the fluid evaporates, which drives the flow within the channel. The system is completely fabricated on flexible polyethylene terephthalate (PET) foils, which can be the backbone material for flexible electronics applications, such that it is compatible with volume production approaches like Roll-to-Roll technology. The evaporation rate can be controlled by varying the outlet geometry and the temperature. The generated flows are analyzed experimentally using Particle Tracking Velocimetry (PTV). Typical results show that with 1 to 61 pores (diameter = 250 μm, pitch = 500 μm) flow rates of 7.3 × 10(-3) to 1.2 × 10(-1) μL/min are achieved. When the surface temperature is increased by 9.4 °C, the flow rate is increased by 130 %. The results are theoretically analyzed using an evaporation model that includes an evaporation correction factor. The theoretical and experimental results are in good agreement. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10544-015-9948-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-43726872015-03-30 A microfluidic device based on an evaporation-driven micropump Nie, Chuan Frijns, Arjan J. H. Mandamparambil, Rajesh den Toonder, Jaap M. J. Biomed Microdevices Article In this paper we introduce a microfluidic device ultimately to be applied as a wearable sweat sensor. We show proof-of-principle of the microfluidic functions of the device, namely fluid collection and continuous fluid flow pumping. A filter-paper based layer, that eventually will form the interface between the device and the skin, is used to collect the fluid (e.g., sweat) and enter this into the microfluidic device. A controllable evaporation driven pump is used to drive a continuous fluid flow through a microfluidic channel and over a sensing area. The key element of the pump is a micro-porous membrane mounted at the channel outlet, such that a pore array with a regular hexagonal arrangement is realized through which the fluid evaporates, which drives the flow within the channel. The system is completely fabricated on flexible polyethylene terephthalate (PET) foils, which can be the backbone material for flexible electronics applications, such that it is compatible with volume production approaches like Roll-to-Roll technology. The evaporation rate can be controlled by varying the outlet geometry and the temperature. The generated flows are analyzed experimentally using Particle Tracking Velocimetry (PTV). Typical results show that with 1 to 61 pores (diameter = 250 μm, pitch = 500 μm) flow rates of 7.3 × 10(-3) to 1.2 × 10(-1) μL/min are achieved. When the surface temperature is increased by 9.4 °C, the flow rate is increased by 130 %. The results are theoretically analyzed using an evaporation model that includes an evaporation correction factor. The theoretical and experimental results are in good agreement. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10544-015-9948-7) contains supplementary material, which is available to authorized users. Springer US 2015-03-25 2015 /pmc/articles/PMC4372687/ /pubmed/25804609 http://dx.doi.org/10.1007/s10544-015-9948-7 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Nie, Chuan
Frijns, Arjan J. H.
Mandamparambil, Rajesh
den Toonder, Jaap M. J.
A microfluidic device based on an evaporation-driven micropump
title A microfluidic device based on an evaporation-driven micropump
title_full A microfluidic device based on an evaporation-driven micropump
title_fullStr A microfluidic device based on an evaporation-driven micropump
title_full_unstemmed A microfluidic device based on an evaporation-driven micropump
title_short A microfluidic device based on an evaporation-driven micropump
title_sort microfluidic device based on an evaporation-driven micropump
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372687/
https://www.ncbi.nlm.nih.gov/pubmed/25804609
http://dx.doi.org/10.1007/s10544-015-9948-7
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