Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here, we report the design and synthesis of a group of near infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to hav...

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Autores principales: Harmsen, Stefan, Bedics, Matthew A., Wall, Matthew A., Huang, Ruimin, Detty, Michael R., Kircher, Moritz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372816/
https://www.ncbi.nlm.nih.gov/pubmed/25800697
http://dx.doi.org/10.1038/ncomms7570
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author Harmsen, Stefan
Bedics, Matthew A.
Wall, Matthew A.
Huang, Ruimin
Detty, Michael R.
Kircher, Moritz F.
author_facet Harmsen, Stefan
Bedics, Matthew A.
Wall, Matthew A.
Huang, Ruimin
Detty, Michael R.
Kircher, Moritz F.
author_sort Harmsen, Stefan
collection PubMed
description High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here, we report the design and synthesis of a group of near infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS-nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumor and disease marker detection.
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spelling pubmed-43728162015-09-24 Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity Harmsen, Stefan Bedics, Matthew A. Wall, Matthew A. Huang, Ruimin Detty, Michael R. Kircher, Moritz F. Nat Commun Article High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here, we report the design and synthesis of a group of near infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS-nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumor and disease marker detection. 2015-03-24 /pmc/articles/PMC4372816/ /pubmed/25800697 http://dx.doi.org/10.1038/ncomms7570 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Harmsen, Stefan
Bedics, Matthew A.
Wall, Matthew A.
Huang, Ruimin
Detty, Michael R.
Kircher, Moritz F.
Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
title Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
title_full Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
title_fullStr Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
title_full_unstemmed Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
title_short Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
title_sort rational design of a chalcogenopyrylium-based surface-enhanced resonance raman scattering-nanoprobe with attomolar sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372816/
https://www.ncbi.nlm.nih.gov/pubmed/25800697
http://dx.doi.org/10.1038/ncomms7570
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