A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors ba...

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Detalles Bibliográficos
Autores principales: Morgan, Rachel E., Chudasama, Vijay, Moody, Paul, Smith, Mark E. B., Caddick, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372856/
https://www.ncbi.nlm.nih.gov/pubmed/25736233
http://dx.doi.org/10.1039/c5ob00130g
Descripción
Sumario:Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.

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