A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors ba...

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Detalles Bibliográficos
Autores principales: Morgan, Rachel E., Chudasama, Vijay, Moody, Paul, Smith, Mark E. B., Caddick, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372856/
https://www.ncbi.nlm.nih.gov/pubmed/25736233
http://dx.doi.org/10.1039/c5ob00130g
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author Morgan, Rachel E.
Chudasama, Vijay
Moody, Paul
Smith, Mark E. B.
Caddick, Stephen
author_facet Morgan, Rachel E.
Chudasama, Vijay
Moody, Paul
Smith, Mark E. B.
Caddick, Stephen
author_sort Morgan, Rachel E.
collection PubMed
description Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.
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spelling pubmed-43728562015-03-27 A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation Morgan, Rachel E. Chudasama, Vijay Moody, Paul Smith, Mark E. B. Caddick, Stephen Org Biomol Chem Chemistry Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones. Royal Society of Chemistry 2015-04-07 2015-03-04 /pmc/articles/PMC4372856/ /pubmed/25736233 http://dx.doi.org/10.1039/c5ob00130g Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Morgan, Rachel E.
Chudasama, Vijay
Moody, Paul
Smith, Mark E. B.
Caddick, Stephen
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
title A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
title_full A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
title_fullStr A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
title_full_unstemmed A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
title_short A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
title_sort novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372856/
https://www.ncbi.nlm.nih.gov/pubmed/25736233
http://dx.doi.org/10.1039/c5ob00130g
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