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The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study

BACKGROUND: Free perforation is the most severe and debilitating complication associated with Crohn’s disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. METHODS: The CrOhn's disease cliN...

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Autores principales: Doh, Young Seok, Kim, You Sun, Bae, Song I, Im, Jong Pil, Cheon, Jae Hee, Ye, Byong Duk, Kim, Ji Won, Park, Young Sook, Lee, Ji Hyun, Kim, Young-Ho, Kim, Joo Sung, Han, Dong Soo, Kim, Won Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373039/
https://www.ncbi.nlm.nih.gov/pubmed/25887913
http://dx.doi.org/10.1186/s12876-015-0262-x
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author Doh, Young Seok
Kim, You Sun
Bae, Song I
Im, Jong Pil
Cheon, Jae Hee
Ye, Byong Duk
Kim, Ji Won
Park, Young Sook
Lee, Ji Hyun
Kim, Young-Ho
Kim, Joo Sung
Han, Dong Soo
Kim, Won Ho
author_facet Doh, Young Seok
Kim, You Sun
Bae, Song I
Im, Jong Pil
Cheon, Jae Hee
Ye, Byong Duk
Kim, Ji Won
Park, Young Sook
Lee, Ji Hyun
Kim, Young-Ho
Kim, Joo Sung
Han, Dong Soo
Kim, Won Ho
author_sort Doh, Young Seok
collection PubMed
description BACKGROUND: Free perforation is the most severe and debilitating complication associated with Crohn’s disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. METHODS: The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics. RESULTS: A total of 1346 patients were analyzed and 88 patients (6.5%) were identified with free perforation in CD. The mean age of the free perforation group was 31.8 ± 13.0 years, which was significantly higher than that of the non-perforated group (27.5 ± 12.1 years) (p = 0.004). Free perforation was the presenting sign of CD in 46 patients (52%). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged ≥ 30 years at diagnosis (OR 2.082, p = 0.002) and bowel strictures (OR 1.982, p = 0.004). The mortality rate in the free perforation group was significantly higher (4.5%) than that in the non-perforated group (0.6%) (p < 0.001). CONCLUSION: The incidence of free perforation in Korean patients with CD was 6.5%. Being aged ≥ 30 years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation.
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spelling pubmed-43730392015-03-26 The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study Doh, Young Seok Kim, You Sun Bae, Song I Im, Jong Pil Cheon, Jae Hee Ye, Byong Duk Kim, Ji Won Park, Young Sook Lee, Ji Hyun Kim, Young-Ho Kim, Joo Sung Han, Dong Soo Kim, Won Ho BMC Gastroenterol Research Article BACKGROUND: Free perforation is the most severe and debilitating complication associated with Crohn’s disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free perforation among Korean patients with CD. METHODS: The CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study was conducted nationwide in Korea, and patients who were diagnosed with CD between 1982 and 2008 were included in this retrospective study. We investigated the incidence of free perforation among these patients and their clinical characteristics. RESULTS: A total of 1346 patients were analyzed and 88 patients (6.5%) were identified with free perforation in CD. The mean age of the free perforation group was 31.8 ± 13.0 years, which was significantly higher than that of the non-perforated group (27.5 ± 12.1 years) (p = 0.004). Free perforation was the presenting sign of CD in 46 patients (52%). Of the 94 perforations that were present in 88 patients, 81 involved the ileum. Multivariate logistic regression analysis determined that free perforation was significantly associated with being aged ≥ 30 years at diagnosis (OR 2.082, p = 0.002) and bowel strictures (OR 1.982, p = 0.004). The mortality rate in the free perforation group was significantly higher (4.5%) than that in the non-perforated group (0.6%) (p < 0.001). CONCLUSION: The incidence of free perforation in Korean patients with CD was 6.5%. Being aged ≥ 30 years at CD diagnosis and bowel strictures were significant risk factors associated with free perforation. BioMed Central 2015-03-18 /pmc/articles/PMC4373039/ /pubmed/25887913 http://dx.doi.org/10.1186/s12876-015-0262-x Text en © Doh et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Doh, Young Seok
Kim, You Sun
Bae, Song I
Im, Jong Pil
Cheon, Jae Hee
Ye, Byong Duk
Kim, Ji Won
Park, Young Sook
Lee, Ji Hyun
Kim, Young-Ho
Kim, Joo Sung
Han, Dong Soo
Kim, Won Ho
The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
title The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
title_full The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
title_fullStr The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
title_full_unstemmed The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
title_short The clinical characteristics of patients with free perforation in Korean Crohn’s disease: results from the CONNECT study
title_sort clinical characteristics of patients with free perforation in korean crohn’s disease: results from the connect study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373039/
https://www.ncbi.nlm.nih.gov/pubmed/25887913
http://dx.doi.org/10.1186/s12876-015-0262-x
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