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Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging

BACKGROUND: Preoperative radiochemotherapy improves outcomes in patients with locally advanced rectal carcinoma, and has been used increasingly in patient management. However, there is a strong clinical need to assess tumor response to neoadjuvant treatment, and a non-invasive technique that allows...

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Autores principales: Li, Lianhuang, Chen, Zhifen, Wang, Xingfu, Li, Hongsheng, Jiang, Weizhong, Zhuo, Shuangmu, Guan, Guoxian, Chen, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373096/
https://www.ncbi.nlm.nih.gov/pubmed/25885576
http://dx.doi.org/10.1186/s12885-015-1157-5
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author Li, Lianhuang
Chen, Zhifen
Wang, Xingfu
Li, Hongsheng
Jiang, Weizhong
Zhuo, Shuangmu
Guan, Guoxian
Chen, Jianxin
author_facet Li, Lianhuang
Chen, Zhifen
Wang, Xingfu
Li, Hongsheng
Jiang, Weizhong
Zhuo, Shuangmu
Guan, Guoxian
Chen, Jianxin
author_sort Li, Lianhuang
collection PubMed
description BACKGROUND: Preoperative radiochemotherapy improves outcomes in patients with locally advanced rectal carcinoma, and has been used increasingly in patient management. However, there is a strong clinical need to assess tumor response to neoadjuvant treatment, and a non-invasive technique that allows the precise identification of morphologic changes in tumors would be of considerable clinical interest. METHODS: In this study, we used multiphoton microscopy (MPM) to detect morphologic alterations in rectal adenocarcinomas in patients treated with preoperative radiochemotherapy. RESULTS: MPM was able to identify histopathologic alterations in rectal cancer following preoperative radiochemotherapy, and allowed the qualitative assessment of treatment efficacy and feasibility in relation to dose or strategy. CONCLUSION: These findings may provide the groundwork for evaluating tumor response to neoadjuvant treatment, thus allowing the tailoring of effective treatment doses and strategies.
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spelling pubmed-43730962015-03-26 Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging Li, Lianhuang Chen, Zhifen Wang, Xingfu Li, Hongsheng Jiang, Weizhong Zhuo, Shuangmu Guan, Guoxian Chen, Jianxin BMC Cancer Research Article BACKGROUND: Preoperative radiochemotherapy improves outcomes in patients with locally advanced rectal carcinoma, and has been used increasingly in patient management. However, there is a strong clinical need to assess tumor response to neoadjuvant treatment, and a non-invasive technique that allows the precise identification of morphologic changes in tumors would be of considerable clinical interest. METHODS: In this study, we used multiphoton microscopy (MPM) to detect morphologic alterations in rectal adenocarcinomas in patients treated with preoperative radiochemotherapy. RESULTS: MPM was able to identify histopathologic alterations in rectal cancer following preoperative radiochemotherapy, and allowed the qualitative assessment of treatment efficacy and feasibility in relation to dose or strategy. CONCLUSION: These findings may provide the groundwork for evaluating tumor response to neoadjuvant treatment, thus allowing the tailoring of effective treatment doses and strategies. BioMed Central 2015-03-18 /pmc/articles/PMC4373096/ /pubmed/25885576 http://dx.doi.org/10.1186/s12885-015-1157-5 Text en © Li et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Li, Lianhuang
Chen, Zhifen
Wang, Xingfu
Li, Hongsheng
Jiang, Weizhong
Zhuo, Shuangmu
Guan, Guoxian
Chen, Jianxin
Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
title Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
title_full Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
title_fullStr Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
title_full_unstemmed Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
title_short Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
title_sort detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373096/
https://www.ncbi.nlm.nih.gov/pubmed/25885576
http://dx.doi.org/10.1186/s12885-015-1157-5
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