Cargando…

Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma

BACKGROUND: Urothelial carcinoma of the bladder (UC) is a common malignancy. Although extensive transcriptome analysis has provided insights into the gene expression patterns of this tumor type, the mechanistic underpinnings of differential methylation remain poorly understood. Multi-level genomic d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aine, Mattias, Sjödahl, Gottfrid, Eriksson, Pontus, Veerla, Srinivas, Lindgren, David, Ringnér, Markus, Höglund, Mattias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373102/ https://www.ncbi.nlm.nih.gov/pubmed/25810763 http://dx.doi.org/10.1186/s13073-015-0144-4

Ejemplares similares

Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems
por: Eriksson, Pontus, et al.
Publicado: (2015)

DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status
por: Lauss, Martin, et al.
Publicado: (2012)

Detailed Analysis of Focal Chromosome Arm 1q and 6p Amplifications in Urothelial Carcinoma Reveals Complex Genomic Events on 1q, and SOX4 as a Possible Auxiliary Target on 6p
por: Eriksson, Pontus, et al.
Publicado: (2013)

Molecular classification of urothelial carcinoma: global mRNA classification versus tumour‐cell phenotype classification
por: Sjödahl, Gottfrid, et al.
Publicado: (2017)

HER2 and EGFR amplification and expression in urothelial carcinoma occurs in distinct biological and molecular contexts
por: Eriksson, Pontus, et al.
Publicado: (2017)

Biological determinants of bladder cancer gene expression subtypes
por: Aine, Mattias, et al.
Publicado: (2015)

Molecular subtype classification of urothelial carcinoma in Lynch syndrome
por: Therkildsen, Christina, et al.
Publicado: (2018)

Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship
por: Marzouka, Nour-Al-Dain, et al.
Publicado: (2020)

Molecular pathology of the luminal class of urothelial tumors
por: Bernardo, Carina, et al.
Publicado: (2019)

A validation and extended description of the Lund taxonomy for urothelial carcinoma using the TCGA cohort
por: Marzouka, Nour-al-dain, et al.
Publicado: (2018)

Genome-wide transcription factor binding site/promoter databases for the analysis of gene sets and co-occurrence of transcription factor binding motifs
por: Veerla, Srinivas, et al.
Publicado: (2010)

Molecular changes during progression from nonmuscle invasive to advanced urothelial carcinoma
por: Sjödahl, Gottfrid, et al.
Publicado: (2019)

Molecular Subtypes as a Basis for Stratified Use of Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer—A Narrative Review
por: Sjödahl, Gottfrid, et al.
Publicado: (2022)

Patient-Derived Bladder Cancer Organoid Models in Tumor Biology and Drug Testing: A Systematic Review
por: Medle, Benjamin, et al.
Publicado: (2022)

Integrated Genomic and Gene Expression Profiling Identifies Two Major Genomic Circuits in Urothelial Carcinoma
por: Lindgren, David, et al.
Publicado: (2012)

A Systematic Study of Gene Mutations in Urothelial Carcinoma; Inactivating Mutations in TSC2 and PIK3R1
por: Sjödahl, Gottfrid, et al.
Publicado: (2011)

A comparison of rule-based and centroid single-sample multiclass predictors for transcriptomic classification
por: Eriksson, Pontus, et al.
Publicado: (2021)

An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells
por: Holm, Karolina, et al.
Publicado: (2016)

Independent component analysis reveals new and biologically significant structures in micro array data
por: Frigyesi, Attila, et al.
Publicado: (2006)

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors
por: Heidenblad, Markus, et al.
Publicado: (2008)

Analysis of promoter regions of co-expressed genes identified by microarray analysis
por: Veerla, Srinivas, et al.
Publicado: (2006)

The Urothelial Transcriptomic Response to Interferon Gamma: Implications for Bladder Cancer Prognosis and Immunotherapy
por: Baker, Simon C., et al.
Publicado: (2022)

SRIQ clustering: A fusion of Random Forest, QT clustering, and KNN concepts
por: Karlström, Jacob, et al.
Publicado: (2022)

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
por: Staaf, Johan, et al.
Publicado: (2008)

Integrated Epigenome Profiling of Repressive Histone Modifications, DNA Methylation and Gene Expression in Normal and Malignant Urothelial Cells
por: Dudziec, Ewa, et al.
Publicado: (2012)

Monitoring of Technical Variation in Quantitative High-Throughput Datasets
por: Lauss, Martin, et al.
Publicado: (2013)

Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
por: Staaf, Johan, et al.
Publicado: (2008)

Tumor purity adjusted beta values improve biological interpretability of high-dimensional DNA methylation data
por: Staaf, Johan, et al.
Publicado: (2022)

EpiMix: an integrative tool for epigenomic subtyping using DNA methylation
por: Zheng, Yuanning, et al.
Publicado: (2023)

EpiMix is an integrative tool for epigenomic subtyping using DNA methylation
por: Zheng, Yuanning, et al.
Publicado: (2023)

The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers
por: Lyko, Frank, et al.
Publicado: (2010)

Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas
por: Shen, Jing, et al.
Publicado: (2015)

Correction: The Honey Bee Epigenomes: Differential Methylation of Brain DNA in Queens and Workers
por: Lyko, Frank, et al.
Publicado: (2011)

Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma
por: Rastogi, Deepa, et al.
Publicado: (2013)

Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
por: Zhang, Xinyu, et al.
Publicado: (2016)

Association of environmental exposure to chromium with differential DNA methylation: An epigenome-wide study
por: Zhao, Meiduo, et al.
Publicado: (2023)

Urodrill - a novel MRI-guided endoscopic biopsy technique to sample and molecularly classify muscle-invasive bladder cancer without fractionating the specimen during transurethral resection
por: Eriksson, Pontus, et al.
Publicado: (2023)

Epigenome-Wide DNA Methylation Profiling Identifies Differential Methylation Biomarkers in High-Grade Bladder Cancer()
por: Olkhov-Mitsel, Ekaterina, et al.
Publicado: (2017)

Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer
por: Olah, Csilla, et al.
Publicado: (2022)

The aging epigenome: DNA methylation from the cradle to the grave
por: Winnefeld, Marc, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_msaasf4bjq42sh6qq6rs45rh88