Evaluation of exon-skipping strategies for Duchenne muscular dystrophy utilizing dystrophin-deficient zebrafish

Duchenne muscular dystophy (DMD) is a severe muscle wasting disease caused by mutations in the dystrophin gene. By utilizing antisense oligonucleotides, splicing of the dystrophin transcript can be altered so that exons harbouring a mutation are excluded from the mature mRNA. Although this approach...

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Detalles Bibliográficos
Autores principales: Berger, Joachim, Berger, Silke, Jacoby, Arie S, Wilton, Steve D, Currie, Peter D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373433/
https://www.ncbi.nlm.nih.gov/pubmed/21251213
http://dx.doi.org/10.1111/j.1582-4934.2011.01260.x

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