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Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study

BACKGROUND: Improvement in health-related quality of life (HRQoL) is one of the main goals in treating chronic obstructive pulmonary disease (COPD). Impaired HRQoL in COPD is associated with increased morbidity and mortality, hospitalisations and burden on our health-care system. The Clinical COPD Q...

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Autores principales: Urff, Manon, van den Berg, Jan-Willem K, Uil, Steven M, Chavannes, Niels H, Damoiseaux, Roger AMJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373458/
https://www.ncbi.nlm.nih.gov/pubmed/25230736
http://dx.doi.org/10.1038/npjpcrm.2014.66
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author Urff, Manon
van den Berg, Jan-Willem K
Uil, Steven M
Chavannes, Niels H
Damoiseaux, Roger AMJ
author_facet Urff, Manon
van den Berg, Jan-Willem K
Uil, Steven M
Chavannes, Niels H
Damoiseaux, Roger AMJ
author_sort Urff, Manon
collection PubMed
description BACKGROUND: Improvement in health-related quality of life (HRQoL) is one of the main goals in treating chronic obstructive pulmonary disease (COPD). Impaired HRQoL in COPD is associated with increased morbidity and mortality, hospitalisations and burden on our health-care system. The Clinical COPD Questionnaire (CCQ) is a validated, reliable, short questionnaire for the evaluation of disease-specific HRQoL in patients with COPD in primary care. AIMS: To investigate factors that might be associated with CCQ outcome in COPD in a primary care setting. METHODS: In a population of COPD patients in primary care, multiple regression analyses were used to assess associations between CCQ outcome and depression, heart failure, FEV(1)% predicted, FEV(1)/FVC, age, sex, body mass index and current smoking. RESULTS: Data from 341 patients (mean age 68.1±10.3, COPD GOLD class I–III) were used for analyses. Together, heart failure and depression explained 23% of the variance in CCQ total score (P<0.001, N=93). Heart failure was most strongly associated with CCQ functional score (27% explained variance, P<0.001, N=100), whereas depression was most strongly associated with CCQ mental score (22% explained variance, P<0.001, N=93). CONCLUSIONS: CCQ outcomes are higher in COPD patients with heart failure and depression. These findings might imply that heart failure and depression affect HRQoL of patients with COPD, and thus emphasise the importance of a holistic approach of this complex disease, leading to a correct diagnosis of COPD and its comorbidities, to achieve better tailored treatment of chronic patients.
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spelling pubmed-43734582015-09-15 Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study Urff, Manon van den Berg, Jan-Willem K Uil, Steven M Chavannes, Niels H Damoiseaux, Roger AMJ NPJ Prim Care Respir Med Article BACKGROUND: Improvement in health-related quality of life (HRQoL) is one of the main goals in treating chronic obstructive pulmonary disease (COPD). Impaired HRQoL in COPD is associated with increased morbidity and mortality, hospitalisations and burden on our health-care system. The Clinical COPD Questionnaire (CCQ) is a validated, reliable, short questionnaire for the evaluation of disease-specific HRQoL in patients with COPD in primary care. AIMS: To investigate factors that might be associated with CCQ outcome in COPD in a primary care setting. METHODS: In a population of COPD patients in primary care, multiple regression analyses were used to assess associations between CCQ outcome and depression, heart failure, FEV(1)% predicted, FEV(1)/FVC, age, sex, body mass index and current smoking. RESULTS: Data from 341 patients (mean age 68.1±10.3, COPD GOLD class I–III) were used for analyses. Together, heart failure and depression explained 23% of the variance in CCQ total score (P<0.001, N=93). Heart failure was most strongly associated with CCQ functional score (27% explained variance, P<0.001, N=100), whereas depression was most strongly associated with CCQ mental score (22% explained variance, P<0.001, N=93). CONCLUSIONS: CCQ outcomes are higher in COPD patients with heart failure and depression. These findings might imply that heart failure and depression affect HRQoL of patients with COPD, and thus emphasise the importance of a holistic approach of this complex disease, leading to a correct diagnosis of COPD and its comorbidities, to achieve better tailored treatment of chronic patients. Nature Publishing Group 2014-09-18 /pmc/articles/PMC4373458/ /pubmed/25230736 http://dx.doi.org/10.1038/npjpcrm.2014.66 Text en Copyright © 2014 Primary Care Respiratory Society UK/Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Urff, Manon
van den Berg, Jan-Willem K
Uil, Steven M
Chavannes, Niels H
Damoiseaux, Roger AMJ
Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study
title Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study
title_full Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study
title_fullStr Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study
title_full_unstemmed Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study
title_short Depression and heart failure associated with clinical COPD questionnaire outcome in primary care COPD patients: a cross-sectional study
title_sort depression and heart failure associated with clinical copd questionnaire outcome in primary care copd patients: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373458/
https://www.ncbi.nlm.nih.gov/pubmed/25230736
http://dx.doi.org/10.1038/npjpcrm.2014.66
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