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Analysis of 1-Minute Potentially Available Fluoride from Dentifrice

Previous reports found that some fluoride-containing dentifrices do not release effective concentrations of fluoride during brushing. Failure to release fluoride can be due to dentifrice matrix components that interfere with the solubilization of the fluoride salts during brushing. A new generation...

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Autores principales: Carey, Clifton M, Holahan, Erin C, Schmuck, Burton D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373608/
https://www.ncbi.nlm.nih.gov/pubmed/25821392
http://dx.doi.org/10.6028/jres.119.025
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author Carey, Clifton M
Holahan, Erin C
Schmuck, Burton D
author_facet Carey, Clifton M
Holahan, Erin C
Schmuck, Burton D
author_sort Carey, Clifton M
collection PubMed
description Previous reports found that some fluoride-containing dentifrices do not release effective concentrations of fluoride during brushing. Failure to release fluoride can be due to dentifrice matrix components that interfere with the solubilization of the fluoride salts during brushing. A new generation of dentifrices has the capability to precipitate beneficial fluoride salts during tooth brushing. Therefore, a method that assesses the potentially available fluoride during the 1-minute brushing is needed. A new filter-paper absorption method to assess the 1-min bioavailable fluoride concentration was developed to meet this need. This method utilizes coiled filter paper that rapidly absorbs the aqueous phase of the dentifrice slurry followed by centrifugation to recover that fluid for fluoride measurement via fluoride ion-selective electrode. The analytical method was used to successfully determine the total fluoride and 1-min bioavailable fluoride in eight dentifrice products containing sodium fluoride (NaF), disodium monofluorophosphate (Na(2)FPO(3), MFP), stannous fluoride (SnF(2)), or NaF with amorphous calcium phosphate (NaF + ACP). The results showed that some of the dentifrices tested had significantly lower potentially available fluoride than the total fluoride. For a MFP-containing sample, aged seven years past its expiry date, there was significant reduction in the bioavailable fluoride compared to MFP products that were not aged. Other than the aged MFP and the SnF(2)-containing samples the bioavailable fluoride for all products tested had at least 80 % of the label fluoride concentration. The filter paper absorption method yielded reproducible results for the products tested with MFP samples showing the largest variations.
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spelling pubmed-43736082015-03-25 Analysis of 1-Minute Potentially Available Fluoride from Dentifrice Carey, Clifton M Holahan, Erin C Schmuck, Burton D J Res Natl Inst Stand Technol Articles Previous reports found that some fluoride-containing dentifrices do not release effective concentrations of fluoride during brushing. Failure to release fluoride can be due to dentifrice matrix components that interfere with the solubilization of the fluoride salts during brushing. A new generation of dentifrices has the capability to precipitate beneficial fluoride salts during tooth brushing. Therefore, a method that assesses the potentially available fluoride during the 1-minute brushing is needed. A new filter-paper absorption method to assess the 1-min bioavailable fluoride concentration was developed to meet this need. This method utilizes coiled filter paper that rapidly absorbs the aqueous phase of the dentifrice slurry followed by centrifugation to recover that fluid for fluoride measurement via fluoride ion-selective electrode. The analytical method was used to successfully determine the total fluoride and 1-min bioavailable fluoride in eight dentifrice products containing sodium fluoride (NaF), disodium monofluorophosphate (Na(2)FPO(3), MFP), stannous fluoride (SnF(2)), or NaF with amorphous calcium phosphate (NaF + ACP). The results showed that some of the dentifrices tested had significantly lower potentially available fluoride than the total fluoride. For a MFP-containing sample, aged seven years past its expiry date, there was significant reduction in the bioavailable fluoride compared to MFP products that were not aged. Other than the aged MFP and the SnF(2)-containing samples the bioavailable fluoride for all products tested had at least 80 % of the label fluoride concentration. The filter paper absorption method yielded reproducible results for the products tested with MFP samples showing the largest variations. [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 2014-12-04 /pmc/articles/PMC4373608/ /pubmed/25821392 http://dx.doi.org/10.6028/jres.119.025 Text en https://creativecommons.org/publicdomain/zero/1.0/ The Journal of Research of the National Institute of Standards and Technology is a publication of the U.S. Government. The papers are in the public domain and are not subject to copyright in the United States. Articles from J Res may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Articles
Carey, Clifton M
Holahan, Erin C
Schmuck, Burton D
Analysis of 1-Minute Potentially Available Fluoride from Dentifrice
title Analysis of 1-Minute Potentially Available Fluoride from Dentifrice
title_full Analysis of 1-Minute Potentially Available Fluoride from Dentifrice
title_fullStr Analysis of 1-Minute Potentially Available Fluoride from Dentifrice
title_full_unstemmed Analysis of 1-Minute Potentially Available Fluoride from Dentifrice
title_short Analysis of 1-Minute Potentially Available Fluoride from Dentifrice
title_sort analysis of 1-minute potentially available fluoride from dentifrice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373608/
https://www.ncbi.nlm.nih.gov/pubmed/25821392
http://dx.doi.org/10.6028/jres.119.025
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