Targeted mutation of NOV/CCN3 in mice disrupts joint homeostasis and causes osteoarthritis-like disease

OBJECTIVE: The matricellular protein NOV/CCN3, is implicated in osteoarthritis (OA) and targeted mutation of NOV in mice (Nov(del3)) leads to joint abnormalities. This investigation tested whether NOV is required for joint homeostasis and if its disruption causes joint degeneration. METHOD: NOV expr...

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Detalles Bibliográficos
Autores principales: Roddy, K.A., Boulter, C.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373756/
https://www.ncbi.nlm.nih.gov/pubmed/25541297
http://dx.doi.org/10.1016/j.joca.2014.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373756/
https://www.ncbi.nlm.nih.gov/pubmed/25541297
http://dx.doi.org/10.1016/j.joca.2014.12.012

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