Would raising the total cholesterol diagnostic cut-off from 7.5 mmol/L to 9.3 mmol/L improve detection rate of patients with monogenic familial hypercholesterolaemia?

A previous report suggested that 88% of individuals in the general population with total cholesterol (TC) > 9.3 mmol/L have familial hypercholesterolaemia (FH). We tested this hypothesis in a cohort of 4896 UK civil servants, mean (SD) age 44 (±6) years, using next generation sequencing to achiev...

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Detalles Bibliográficos
Autores principales: Futema, M., Kumari, M., Boustred, C., Kivimaki, M., Humphries, S.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373788/
https://www.ncbi.nlm.nih.gov/pubmed/25682026
http://dx.doi.org/10.1016/j.atherosclerosis.2015.01.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373788/
https://www.ncbi.nlm.nih.gov/pubmed/25682026
http://dx.doi.org/10.1016/j.atherosclerosis.2015.01.028

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