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Activation of HIFa Pathway in Mature Osteoblasts Disrupts the Integrity of the Osteocyte/Canalicular Network

The hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, are the central mediators of the homeostatic response that enables cells to survive and differentiate in low-oxygen conditions. Previous studies indicated that disruption of the von Hippel-Lindau gene (Vhl) coincides with the activation of HIF...

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Detalles Bibliográficos
Autores principales:	Zuo, Gui-lai, Zhang, Lian-fang, Qi, Jin, Kang, Hui, Jia, Peng, Chen, Hao, Shen, Xing, Guo, Lei, Zhou, Han-bing, Wang, Jin-shen, Zhou, Qi, Qian, Nian-dong, Deng, Lian-fu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373796/ https://www.ncbi.nlm.nih.gov/pubmed/25806791 http://dx.doi.org/10.1371/journal.pone.0121266

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