The PAX3-FOXO1 Fusion Protein Present in Rhabdomyosarcoma Interferes with Normal FOXO Activity and the TGF-β Pathway

PAX3-FOXO1 (PAX3-FKHR) is the fusion protein produced by the genomic translocation that characterizes the alveolar subtype of Rhabdomyosarcoma, a pediatric sarcoma with myogenic phenotype. PAX3-FOXO1 is an aberrant but functional transcription factor. It retains PAX3-DNA-binding activity and functio...

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Detalles Bibliográficos
Autores principales: Schmitt-Ney, Michel, Camussi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373809/
https://www.ncbi.nlm.nih.gov/pubmed/25806826
http://dx.doi.org/10.1371/journal.pone.0121474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373809/
https://www.ncbi.nlm.nih.gov/pubmed/25806826
http://dx.doi.org/10.1371/journal.pone.0121474

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