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Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study

The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence-discriminatory mechanism at the Sec61 protein-conducting channel. However, it was not clear how selective cotransin is, i.e. how many proteins are sensitive. Moreover, a conse...

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Detalles Bibliográficos
Autores principales:	Klein, Wolfgang, Westendorf, Carolin, Schmidt, Antje, Conill-Cortés, Mercè, Rutz, Claudia, Blohs, Marcus, Beyermann, Michael, Protze, Jonas, Krause, Gerd, Krause, Eberhard, Schülein, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373898/ https://www.ncbi.nlm.nih.gov/pubmed/25806945 http://dx.doi.org/10.1371/journal.pone.0120886

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