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Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells

Acute myeloid leukemia is a clonal malignant disorder derived from a small number of leukemic stem cells (LSCs). Rearrangements of the mixed lineage leukemia (MLL) gene are found in acute myeloid leukemia associated with poor prognosis. The upregulation of Hox genes is critical for LSC induction and...

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Detalles Bibliográficos
Autores principales:	Aikawa, Yukiko, Yamagata, Kazutsune, Katsumoto, Takuo, Shima, Yutaka, Shino, Mika, Stanley, E Richard, Cleary, Michael L, Akashi, Koichi, Tenen, Daniel G, Kitabayashi, Issay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373983/ https://www.ncbi.nlm.nih.gov/pubmed/25529853 http://dx.doi.org/10.1111/cas.12593

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