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Life at the mesoscale: the self-organised cytoplasm and nucleoplasm

The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based motor networks and multi-scale chromatin organisation. The challenges of mesoscale self-organ...

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Detalles Bibliográficos
Autores principales: Sear, Richard P, Pagonabarraga, Ignacio, Flaus, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374369/
https://www.ncbi.nlm.nih.gov/pubmed/25815164
http://dx.doi.org/10.1186/s13628-015-0018-6
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author Sear, Richard P
Pagonabarraga, Ignacio
Flaus, Andrew
author_facet Sear, Richard P
Pagonabarraga, Ignacio
Flaus, Andrew
author_sort Sear, Richard P
collection PubMed
description The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based motor networks and multi-scale chromatin organisation. The challenges of mesoscale self-organisation were discussed at a CECAM workshop in July 2014. Biologists need approaches to observe highly dynamic, low affinity, low specificity associations and to perturb single structures, while biological physicists and biomathematicians need to work closely with biologists to build and validate quantitative models. A table of terminology is included to facilitate multidisciplinary efforts to reveal the richness and diversity of mesoscale cell biology.
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spelling pubmed-43743692015-03-27 Life at the mesoscale: the self-organised cytoplasm and nucleoplasm Sear, Richard P Pagonabarraga, Ignacio Flaus, Andrew BMC Biophys Correspondence The cell contains highly dynamic structures exploiting physical principles of self-organisation at the mesoscale (100 nm to 10 μm). Examples include non-membrane bound cytoplasmic bodies, cytoskeleton-based motor networks and multi-scale chromatin organisation. The challenges of mesoscale self-organisation were discussed at a CECAM workshop in July 2014. Biologists need approaches to observe highly dynamic, low affinity, low specificity associations and to perturb single structures, while biological physicists and biomathematicians need to work closely with biologists to build and validate quantitative models. A table of terminology is included to facilitate multidisciplinary efforts to reveal the richness and diversity of mesoscale cell biology. BioMed Central 2015-02-25 /pmc/articles/PMC4374369/ /pubmed/25815164 http://dx.doi.org/10.1186/s13628-015-0018-6 Text en © Sear et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Correspondence
Sear, Richard P
Pagonabarraga, Ignacio
Flaus, Andrew
Life at the mesoscale: the self-organised cytoplasm and nucleoplasm
title Life at the mesoscale: the self-organised cytoplasm and nucleoplasm
title_full Life at the mesoscale: the self-organised cytoplasm and nucleoplasm
title_fullStr Life at the mesoscale: the self-organised cytoplasm and nucleoplasm
title_full_unstemmed Life at the mesoscale: the self-organised cytoplasm and nucleoplasm
title_short Life at the mesoscale: the self-organised cytoplasm and nucleoplasm
title_sort life at the mesoscale: the self-organised cytoplasm and nucleoplasm
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374369/
https://www.ncbi.nlm.nih.gov/pubmed/25815164
http://dx.doi.org/10.1186/s13628-015-0018-6
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