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Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

BACKGROUND: CD2-associated protein (CD2AP) is an SH3-containing scaffold adaptor protein which regulates the actin cytoskeleton. Recently, CD2AP was identified as a genetic risk factor for Alzheimer’s disease (AD) by several genome-wide association studies. One of the hallmarks of AD is the accumula...

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Detalles Bibliográficos
Autores principales:	Liao, Fan, Jiang, Hong, Srivatsan, Subhashini, Xiao, Qingli, Lefton, Katheryn B, Yamada, Kaoru, Mahan, Thomas E, Lee, Jin-Moo, Shaw, Andrey S, Holtzman, David M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374406/ https://www.ncbi.nlm.nih.gov/pubmed/25887956 http://dx.doi.org/10.1186/s13024-015-0006-y

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