The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K(2). Here, we show that sterols s...

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Detalles Bibliográficos
Autores principales: Schumacher, Marc M, Elsabrouty, Rania, Seemann, Joachim, Jo, Youngah, DeBose-Boyd, Russell A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374513/
https://www.ncbi.nlm.nih.gov/pubmed/25742604
http://dx.doi.org/10.7554/eLife.05560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374513/
https://www.ncbi.nlm.nih.gov/pubmed/25742604
http://dx.doi.org/10.7554/eLife.05560

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